Interferon-induced human (2'-5') oligo A synthetase

Details Interferon-induced human (2'-5') oligo A synthetase Interferon-induced human (2'-5') oligo A synthetase

1987-04-08

1991-12-10

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

435 6, 435 71, 435 74, 435 79, 435 91, 435810, 436501, 436504, 436 86, 436800, 436804, 436813, 424 858, 935110, A61K 3704, G01N 33532

Patent

active

050719637

ABSTRACT:
Human DNA encoding enzymes having (2'-5') oligo A synthetase has been sequenced. The amino acid sequences of the enzymes have been deduced. Antigenic peptides have been prepared and have been used to raise antibodies which recognize and immunoprecipitate the 40 kd, 46 kd, 67 kd and 100 kd forms of (2'-5') oligo A synthetase. Methods of monitoring interferon activity in a subject are presented.

REFERENCES:
Shimizu et al. (1983) J. of Biochemistry, vol. 94, No. 5, pp. 1421-1428.

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