Interferon-induced (2'-5') oligo a synthetase gene, mRNA, cDNA a

Details Interferon-induced (2'-5') oligo a synthetase gene, mRNA, cDNA a Interferon-induced (2'-5') oligo a synthetase gene, mRNA, cDNA a

1986-02-25

1991-11-05

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 6, 435 691, 435 711, 435 91, 4351221, 4351723, 435183, 43525233, 4353201, 536 27, 935 6, 935 9, 935 22, 935 29, 935 60, 935 72, 935 73, C12N 121, C12N 900, C12N 1552, C12N 1570

Patent

active

050631594

ABSTRACT:
Human DNA encoding enzymes having (2'-5') oligo A synthetase has been sequenced. The amino acid sequences of the enzymes have been deduced. Antigenic peptides have been prepared which may be used to raise antibodies which recognize and immunoprecipitate (2'-5') oligo A synthetase. Methods of monitoring interferon activity in a subject are presented.

REFERENCES:
Biological Abstracts, 76(7): 48835, Young et al. 1983 Pnas 80(5): 1194-1198, Efficient Isolation Of Genes by Using Antibody Probes.
Yang et al. 1981 J. Biol. Chem. 256(17l:9324-9328.
Suggs et al. 1981 PNAS 78(11l:6613-6617.
Maniatis et al., 1982, Molecular Cloning, Cold Spring Harbor.
Benech, P. et al. (Sep., 1985), EMBO J., 4: 2249-2256.
Chebath, J. et al. (1983), The Biology of the Interferon System, pp. 223-229, E. DeMaeyer and H. Schellekens (eds).
Gazitt, Y. et al. (1984), Clin Imm. & Imm. 30: 71-79.
Merlin, G. et al. (Aug. 1983), Proc. Nat'l. Acad. Sci. (U.S.A.) 80: 4904-4908.
Chebath, J. et al. (Mar. 11, 1983), Nucleic Acids Research 11: 1213-1224.
Benech, P. et al. (Feb. 25, 1985), Nucleic Acids Research 13: 1267-1281.

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