Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1995-07-14
1999-06-15
Fitzgerald, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530413, 435 6952, 424 851, 424 852, C07K 1454, C12N 1524
Patent
active
059123249
ABSTRACT:
A protein which induces IFN-.gamma. production by immunocompetent cells and has a molecular weight of 19,000.+-.5,000 daltons on SDS-PAGE or gel filtration and a pI of 4.8.+-.1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein.
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Locksley, "Interleukin 12 In Host Defense Against Microbial Pathogens", Proceedings of the National Academy of Sciences of USA, vol. 90, pp. 5879-5880, Jul. 1993.
Kohno Keizo
Kunikata Toshi
Kurimoto Masashi
Okamura Haruki
Taniguchi Mutsuko
Fitzgerald David L.
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
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