Interferon gamma conjugates

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

Reexamination Certificate

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C424S085400, C424S085500, C424S185100, C435S069510

Reexamination Certificate

active

10130084

ABSTRACT:
A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence that differs from that of a parent IFNG polypeptide in at least one introduced and/or at least one removed amino acid residue comprising an attachment group for the non-polypeptide moiety. The conjugate may be used for treatment of various diseases.

REFERENCES:
patent: 4457867 (1984-07-01), Ishida
patent: 4588585 (1986-05-01), Mark et al.
patent: 4604284 (1986-08-01), Kung et al.
patent: 4695623 (1987-09-01), Stabinsky
patent: 4727138 (1988-02-01), Goeddel et al.
patent: 4758656 (1988-07-01), Itoh et al.
patent: 4762791 (1988-08-01), Goeddel et al.
patent: 4832959 (1989-05-01), Engels et al.
patent: 4835256 (1989-05-01), Taniguchi et al.
patent: 4845196 (1989-07-01), Cowling
patent: 4855238 (1989-08-01), Gray et al.
patent: 4897471 (1990-01-01), Stabinsky
patent: 4898931 (1990-02-01), Itoh et al.
patent: 4904584 (1990-02-01), Shaw
patent: 4921698 (1990-05-01), Shirai et al.
patent: 4925793 (1990-05-01), Goeddel et al.
patent: 4929554 (1990-05-01), Goeddel et al.
patent: 4944941 (1990-07-01), Ammann
patent: 4966843 (1990-10-01), McCormick et al.
patent: 4980455 (1990-12-01), Sakaguchi et al.
patent: 5004689 (1991-04-01), Fiers et al.
patent: 5041376 (1991-08-01), Gething et al.
patent: 5096705 (1992-03-01), Goeddel et al.
patent: 5109120 (1992-04-01), Ueno et al.
patent: 5157004 (1992-10-01), Sakaguchi et al.
patent: 5362490 (1994-11-01), Kurimoto et al.
patent: 5376567 (1994-12-01), McCormick et al.
patent: 5382657 (1995-01-01), Karasiewicz et al.
patent: 5518899 (1996-05-01), Kurimoto et al.
patent: 5541293 (1996-07-01), Stabinsky
patent: 5554515 (1996-09-01), Kurimoto et al.
patent: 5574137 (1996-11-01), Gray et al.
patent: 5582824 (1996-12-01), Goeddel et al.
patent: 5595888 (1997-01-01), Gray et al.
patent: 5661009 (1997-08-01), Stabinsky
patent: 5672692 (1997-09-01), Kurimoto et al.
patent: 5690925 (1997-11-01), Gray et al.
patent: 5711944 (1998-01-01), Gilbert et al.
patent: 5723121 (1998-03-01), Takenaga et al.
patent: 5738846 (1998-04-01), Greenwald et al.
patent: 5747646 (1998-05-01), Hakimi et al.
patent: 5770191 (1998-06-01), Johnson et al.
patent: 5792834 (1998-08-01), Hakimi et al.
patent: 6042822 (2000-03-01), Gilbert et al.
patent: 6046034 (2000-04-01), Waschutza et al.
patent: 6120762 (2000-09-01), Johnson et al.
patent: 6497871 (2002-12-01), Gray et al.
patent: 2096532 (1992-05-01), None
patent: 077 670 (1983-04-01), None
patent: 088 540 (1983-09-01), None
patent: 089 676 (1983-09-01), None
patent: 098 110 (1984-01-01), None
patent: 110 044 (1984-06-01), None
patent: 146 354 (1985-06-01), None
patent: 158 198 (1985-10-01), None
patent: 170 917 (1986-02-01), None
patent: 219 781 (1987-04-01), None
patent: 229 108 (1987-07-01), None
patent: 256 424 (1987-08-01), None
patent: 236 987 (1987-09-01), None
patent: 237 019 (1987-09-01), None
patent: 306 870 (1989-03-01), None
patent: 121 157 (1989-06-01), None
patent: 145 174 (1989-09-01), None
patent: 370 205 (1990-05-01), None
patent: 446 582 (1991-09-01), None
patent: 546 099 (1994-10-01), None
patent: 795 332 (1997-09-01), None
patent: 593 868 (1998-04-01), None
patent: 860 442 (1998-08-01), None
patent: 92/08737 (1991-11-01), None
patent: 92/22310 (1992-06-01), None
patent: 99/03887 (1998-07-01), None
patent: 99/67291 (1999-06-01), None
patent: 01/23006 (2000-09-01), None
patent: 01/36001 (2000-11-01), None
Arakawa, et al. ,Role of Polycationic c-terminal Portion in the Structure and Activity of Recombinant Human Interferon-γ, The Journal of Biological Chemistry, 261(18), Jun. 25, pp. 8534-8539 (1986).
Arakawa, et al.,Structure and Activity of Glycosylated Human Interferon-γ, Journal of Interferon Research, 6:687-695 (1986).
Bulleid, et al.,Source of heterogeneity in secreted interferon-γ, Biochem, J. 268:777-781 (1990).
Cantell, et al.,Differential Inactivation of Interferon by a Protease from Human Granulocytes, Journal of Inerferon Research 12:177-183 (1992).
Castro, et al.,The macroheterogeneity of recombinant human interferon-γ produced by Chinese-hamster ovary cells is affected by the protein and lipid content of the culture medium, Biotechnol. Appl. Biochem., 21:87-100 (1995).
Curling, et al. ,Recombinant human interferon-γ, Differences in glycosylation and proteolytic processing lead to heterogeneity in batch culture, Biochem. J., 272:333-337 (1990).
Devos, et al.,Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells, Nucleic Acids Research, 10(8), 2487-2501, Nov. 8, 1982.
Ealick, et al.,Three-Dimensional Structure of Recombinant Human Interferon-γ, Science, 252:698-702 (1991).
Farrar, et al.,The Molecular Cell Biology of Interferon-γ and its Receptor, Annu. Rev. Immunol. 11:572-611 (1993).
Gray, et al.,Structure of the human immune interferon gene, Nature, 298:859-863 (Aug. 1992).
Griggs, et al.,The N-terminus and C-Terminus of IFNγ Are Binding Domains for Cloned Soluble lFN-γ Receptor, The Journal of Immunology, 149(2) 517-520 (Jul. 15, 1992).
Gu, et al.,Improvement of Interferonγ Sialylation in Chinese Hamster Ovary Cell culture by Feeding of N-Acetylmannosamine, Biotechnology & Bioengineering, 58(6) 642-648 (1998).
Haelewn, et al.,Interaction of truncated human interferon γ variants with the interferon γ receptor: crucial importance of Arg-129, Biochem. J., 324, 591-595 (1997).
Harmon, et al.,Rapid Monitoring of Site-Specific Glycosylation Microheterogeneity of Recombinant Human Interferon-γ, Anal. Chem., 68(9) 1465-1473 (1996).
Hogrefe, et al.,Amino Terminus Is Essential to the Structural Integrity of Recombinant Human Interferon-γ, The Journal of Biological Chemistry, 264(21) 12179-86 (1989).
Hooker, et al.,Constraints on the Transport and Glycosylation of Recombinant IFN-γ in Chinese Hamster Ovary and Insect Cells, Biotechnology & Bioengineering, 63(5) 559-572 (1999).
Hsu, et al.,Structure and activity of Recombinant Human Interferon-γ Analogs, Journal of Interferon Research, 6:663-670 (1986).
James, et al.,N-Glycosylation of Recombinant Human Interferon-γ Produced in Different Animal Expression Systems, Bio/Technology, 13:592-96 (Jun. 13, 1995).
Kita, et al.,Characterization of a Polyethylene Glycol Conjugate of Recombinant Human Interferon-γ, Drug Design and Delivery, 6:157-167 (1990).
Kontsek, et al.,Engineered Acid-Stable Human Interferon Gamma, Cytokine, 12(6) 708-710 (Jun. 2000.
Landar, et al.,Design, Characterization, and Structure of a Biologically Active Single-chain Mutant of Human IFN-γ, J. Mol. Biol., 299:169-179 (2000).
Leinikki, et al.,Reduced Receptor Binding by a Human Interferonγ Fragment Lacking 11 Carboxyl-Terminal Amino Acids, Journal of Immunology, 139(10) 3360-3366 (1987).
Littman, et al.,Binding of Unglycosylated and Glycosylated Human Recombinant Interferon-γ to Cellular Receptors, Journal of Interferon Research, 5: 471-476 (1985).
Lord, et al.,Functional Domains of Human Interferon Gamma Probed With Antipeptide Antibodies, Molecular Immunology, 26(7) 637-640 (1989).
Luk, et al.,Structure-Function Analysis of the Human Interferon γ, The Journal of Biological Chemistry, 265 (22) 13314-13319 (1990).
Lundell, et al.,Importance of the Loop connecting A and B Helices of Human Interferon-γ in Recognition by Interferon-γ Receptor*, The Journal of Biological Chemistry, 269(23) 16159-16162.
Lundell, et al.,Structural Elements Required for Receptor Recognition of Human Interferon-Gamma, Pharmac. Ther. 64:1-21 (1994).
Lundell, et al.,The carboxyl-terminal region of human interferon γ is important for biological activity: mutagenic and NMR analysis, Protein Engineering, 4(3) 335-341 (1991).
Lunn, et al.,A point mutation of human interferon γ abolishes receptor recognition, Protein Engineering, 5(3) 253-257 (1992).
Lunn, et al.,A point mutation that decreases the thermal stability of human interf

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