Interferon epsilon

Details Interferon epsilon Interferon epsilon

1984-07-06

1986-09-30

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

435 68, 435804, 530351, A61K 4502, C12P 2100

Patent

active

046146512

ABSTRACT:
Disclosed is a new material having antiviral activity designated interferon epsilon. The material may be produced, for example, by exposing primary, diploid human epithelial cells to a virus and then incubating the cells under conditions in which the new interferon is produced and is secreted into the culture medium. The material is antigenically distinct from interferon alpha, interferon beta, and interferon gamma, and displays marked antiviral activity in human epithelial cells but no detectable activity in other cell types.

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patent: 4016036 (1977-04-01), Green
Chemical Abstracts, vol. 94, p. 441, Abst. No. 206918e, 1981.
Ferreira, P., et al., Interferon; Properties and Clinical Uses, pp. 121-126, 1979.
Fournier, F., et al., J. Immunology, vol. 99, pp. 1036-1040, 1967.
Jameson, et al., Archives of Virology, vol. 62, pp. 209-219, 1979.
Eihorn et al., J. Gen. Virol., vol. 35, pp. 573-577, 1977.
Goeddel et al., Nature, vol. 287, pp. 411-416, 1980.
The Interferon System, W. E. Stewart, II, 1981, Springer-Verlag/Wien.

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