Interferon administration vehicles

Drug – bio-affecting and body treating compositions – Lymphokine

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424 83, A61K 4502, A61K 31745

Patent

active

046801758

ABSTRACT:
An interferon preparation to be administered topically is provided comprising: (a) a therapeutically effective amount of one or more interferons; (b) a vehicle base compatible with the interferon or interferons being administered; (c) an effective amount of one or more protease inhibitors for the purpose of reducing the rate of decay of the biological activity of the interferon or interferons due to proteolytic agents; and (d) an effective amount of one or more anti-microbial agents. In certain preferred embodiments of the invention, the vehicle base is prepared from a mixture of polyethylene glycols or includes hydroxyethyl cellulose as a thickening agent.

REFERENCES:
patent: 4348384 (1982-09-01), Horikoshi et al.
patent: 4478822 (1984-10-01), Haslam et al.
patent: 4507281 (1985-03-01), Asculai et al.
Remington's Pharmaceutical Sciences, 15th Ed., (Arthur Osol, Ed.), Mack Pub. Co., Easton, PA, 1975, pp. 1243-1253.
Mihalyi, E., Appl. of Proteolytic Enzymes to Protein Structure Studies vol. 1, 2d ed, CRC Press, Boca Raton, FL, 1978, pp. 43-54 and 114-127.
Moller et al., Third Annual International Congress for Interferon Research, 1982.

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