Interfering RNA molecules

Details Interfering RNA molecules Interfering RNA molecules

2003-08-05

2008-11-18

McGarry, Sean (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S024100, C536S024310, C536S024320, C536S024330, C536S024300

Reexamination Certificate

active

07452987

ABSTRACT:
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double-stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and whereby said first stretch is at least partially complementary to a target nucleic acid, and the second strand comprises a second stretch of contiguous nucleotides whereby said second stretch is at least partially identical to a target nucleic acid, and whereby the double stranded structure is blunt ended.

REFERENCES:
patent: 4217294 (1980-08-01), Petty
patent: 5466786 (1995-11-01), Buhr et al.
patent: 5514546 (1996-05-01), Kool
patent: 5589389 (1996-12-01), Pages et al.
patent: 5670633 (1997-09-01), Cook et al.
patent: 5792847 (1998-08-01), Buhr et al.
patent: 5872232 (1999-02-01), Cook et al.
patent: 5898031 (1999-04-01), Crooke
patent: 5914396 (1999-06-01), Cook et al.
patent: 5955589 (1999-09-01), Cook et al.
patent: 6005087 (1999-12-01), Cook et al.
patent: 6107094 (2000-08-01), Crooke
patent: 6129912 (2000-10-01), Hortin et al.
patent: 6153737 (2000-11-01), Manoharan et al.
patent: 6239272 (2001-05-01), Beigelman et al.
patent: 6284267 (2001-09-01), Aneja
patent: 6476205 (2002-11-01), Buhr et al.
patent: 6506559 (2003-01-01), Fire et al.
patent: 6531584 (2003-03-01), Cook et al.
patent: 6617438 (2003-09-01), Beigelman et al.
patent: 6812204 (2004-11-01), McHale et al.
patent: 7056704 (2006-06-01), Tuschl et al.
patent: 7074863 (2006-07-01), Ekholm et al.
patent: 7078196 (2006-07-01), Tuschl et al.
patent: 7138517 (2006-11-01), Cook et al.
patent: 7148342 (2006-12-01), Tolentino et al.
patent: 7196184 (2007-03-01), Heidenreich et al.
patent: 7348314 (2008-03-01), John et al.
patent: 2003/0027783 (2003-02-01), Zernicka-Goetz et al.
patent: 2003/0108923 (2003-06-01), Tuschl et al.
patent: 2003/0135033 (2003-07-01), Klippel-Giese et al.
patent: 2003/0190635 (2003-10-01), McSwiggen
patent: 2004/0053875 (2004-03-01), Kreutzer et al.
patent: 2004/0072779 (2004-04-01), Kreutzer et al.
patent: 2004/0102408 (2004-05-01), Kreutzer et al.
patent: 2004/0106569 (2004-06-01), Klippel-Giese et al.
patent: 2004/0175703 (2004-09-01), Kreutzer et al.
patent: 2004/0180351 (2004-09-01), Giese et al.
patent: 2004/0229266 (2004-11-01), Tuschl et al.
patent: 2005/0043263 (2005-02-01), Giese et al.
patent: 2005/0100907 (2005-05-01), Kreutzer et al.
patent: 2005/0142535 (2005-06-01), Damha et al.
patent: 2006/0094678 (2006-05-01), Vornlocher et al.
patent: 2006/0142226 (2006-06-01), Polisky et al.
patent: 2006/0217329 (2006-09-01), Feinstein
patent: 2006/0240022 (2006-10-01), Klippel-Giese et al.
patent: 2007/0027097 (2007-02-01), Lewis
patent: 2007/0093445 (2007-04-01), Tuschl et al.
patent: 2007/0135372 (2007-06-01), MacLachlan et al.
patent: 2007/0265220 (2007-11-01), Rossi et al.
patent: 02018572.4 (2002-08-01), None
patent: 1 230 375 (2005-07-01), None
patent: 1 527 176 (2007-01-01), None
patent: 1 407 044 (2007-09-01), None
patent: 2417727 (2008-01-01), None
patent: WO 92/07065 (1992-04-01), None
patent: WO 92/19732 (1992-11-01), None
patent: WO 94/01550 (1994-01-01), None
patent: WO 96/18736 (1996-06-01), None
patent: WO 97/46570 (1997-12-01), None
patent: WO 98/05770 (1998-02-01), None
patent: WO 98/53083 (1998-11-01), None
patent: WO 99/15682 (1999-04-01), None
patent: WO 99/32619 (1999-07-01), None
patent: WO 99/49029 (1999-09-01), None
patent: WO 99/53050 (1999-10-01), None
patent: WO 99/55857 (1999-11-01), None
patent: WO 99/61631 (1999-12-01), None
patent: WO 00/01846 (2000-01-01), None
patent: WO 00/44495 (2000-08-01), None
patent: WO 00/44895 (2000-08-01), None
patent: WO 00/44914 (2000-08-01), None
patent: WO 00/63364 (2000-10-01), None
patent: WO 01/36646 (2001-05-01), None
patent: WO 01/75164 (2001-10-01), None
patent: WO 02/16620 (2002-02-01), None
patent: WO 02/44321 (2002-06-01), None
patent: WO 02/055693 (2002-07-01), None
patent: WO 02/097114 (2002-12-01), None
patent: WO 03/064441 (2003-08-01), None
patent: WO 03/070895 (2003-08-01), None
patent: WO 03/070918 (2003-08-01), None
patent: WO 2004/015107 (2004-02-01), None
patent: WO 2004/019973 (2004-03-01), None
patent: WO 2004/035615 (2004-04-01), None
patent: WO 2005/000320 (2005-01-01), None
patent: WO 2005/105152 (2005-11-01), None
patent: WO 2006/023544 (2006-03-01), None
patent: WO 2006/069782 (2006-07-01), None
patent: WO 2007/048244 (2007-05-01), None
patent: WO 2007/084684 (2007-07-01), None
Holen et al. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Research, 2002, vol. 30, No. 8: 1757-1766. Oxford University Press.
The Merriam Webster Dictionary, pp. 37 and 540. 1997 Merriam-Webster, Inc.
Holen et al. Positional effects of short intefering RNAs targeting the human coagulation trigger Tissue Factor. Nucleic Acids Research (2002) vol. 30, No. 8: 1757-1766. Oxford University Press.
Mahato et al. Modulation of gene expression by antisense and antigene oligodeoxynucleotides and small interfering RNA. Expert. Opin. Deliv. 2005, vol. 2(1): 3-28.
Scherer et al. Approaches for the Sequence-specific knockdown of mRNA (Nat. Biotechnol., 2003, 21(12), pp. 1457-1465).
Zhang et al. Targeted Gene Silencing by Small Interfering RNA based Knock-down TEchnology. Current Pharmaceutical Biotechnology 2004, vol. 5, pp. 1-7.
Robert Barstead, “Genome-wide RNAi”, Current Opinion in Chemical Biology, 2001, pp. 63-66, vol. 5.
David C. Baulcombe, “Fast forward genetics based on virus-induced gene silencing”, Current Opinion in Plant Biology, 1999, pp. 109-113, vol. 2.
Emily Bernstein et al., “Role for a bidentate ribonuclease in the initiation step of RNA interference”, Nature, Jan. 18, 2001, p. 363-366, vol. 409.
Eric Billy et al., “Specific Interference with Gene Expression Induced by Long, Double-Stranded RNA in Mouse Embryonal Teratocarcinoma Cell Lines”, Proceedings of the National Academy of Sciences of the United States of America, Dec. 4, 2001, pp. 14428-14433, vol. 98, No. 25.
Christian Cazenave et al., “Rate of degradation of [α]- and [β]- oligodeoxynucleotides inXenopusoocytes. Implications for anti-messenger strategies”, Nucleic Acids Research, 1987, pp. 10507-10521, vol. 15, No. 24.
Sayda M. Elbashir et al., “Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells”, Nature, May 24, 2001, pp. 494-498, vol. 411.
Andrew Fire, “RNA-triggered gene silencing”, TIG, Sep. 1999, pp. 358-363, vol. 15, No. 9.
Jason R. Kennerdell et al., “Heritable gene silencing inDrosophilausing double-standard RNA”, Nature Biotechnology, Jul. 2000, pp. 896-898, vol. 17.
Jason R. Kennerdell et al., “Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway”, Cell, Dec. 23, 1998, pp. 1017-1026, vol. 95.
Stuart K. Kim, “Functional genomics: The worm scores a knockout”, Current Biology, 2001, pp. R85-R87, vol. 11.
Ikuma Maeda et al., “Large-scale analysis of gene function inCaenorhabditis elegansby high-throughput RNAi”, Current Biology, 2001, pp. 171-176, vol. 11.
Mary K. Montgomerry et al., “RNA as a Target of Double-Stranded RNA-Mediated Genetic Interference inCaenorhabditis elegans”, Proceedings of the National Academy of Science of the United States of America, Dec. 22, 1998, pp. 15502-15507, vol. 95, No. 26.
Antti Nyk{hacek over (a)}nen et al., “ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway”, Cell, No. 2, 2001, pp. 309-321, vol. 107.
Phillip A. Sharp, “RNA interference-2001”, Genes & Development, 2001, pp. 485-490, vol. 15.
Maria Sternberger et al., “GeneBlocs Are Powerful Tools to Study and Delineate Signal Transduction Process That Regulate Cell Growth and Transformation”, Antisense & Nucleic Acid Drug Development, 2002, pp. 131-143, vol. 12.
Thomas Tuschl et al., “Targete

Affiliated with

Also associated with

Rating

Interfering RNA molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Interfering RNA molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interfering RNA molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4023987