Interference of b-type retrovirus replication with a tripeptide

Details Interference of b-type retrovirus replication with a tripeptide Interference of b-type retrovirus replication with a tripeptide

1985-03-14

1988-04-26

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 4352402, 43524021, A61K 3702, C12N 502

Patent

active

047405015

ABSTRACT:
The cancericidal activity of all the permutations of a tripeptide compound formed from dichlorodiethylaminophenylalanine, parafluorophenylalanine and methionine bonded together with peptide links was demonstrated using seven in vitro tumor cell lines. The viabilities of each of the tumor cell lines were significantly reduced by treatment for 1 to 24 hours with 1 to 50 ug of the tripeptide per ml of carrier solvent. A pulse exposure to the tripeptide demonstrated that the reductions in tumor cell was comparable to continuous exposure. Other in vitro tests were all conducted on AKR mice.
Method of treating virus by exposing the virus to one of the noted tripeptides compounds is also contemplated.
Methods of treating tumor cells with the tripeptides dissolved in a solvent consisting of dimethylacetamide, propylene glycol and absolute ethanol are also contemplated by the present invention.
Methods of treating tumor cells resistant to other chemotherapeutic agents is contemplated by this invention.
Methods of treating mouse mammary tumor cells to reduce production of the B-type retrovirus, mouse mammary tumor virus (MMTV), is contemplated by this invention.

REFERENCES:
patent: 4087520 (1978-05-01), Bran et al.
patent: 4127534 (1978-11-01), Coy et al.
patent: 4153688 (1979-05-01), Demecoli et al.
patent: 4540683 (1985-09-01), DeBarbieri et al.

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