Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-10-10
1992-11-24
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303913, 5303915, 5303917, 5303919, 530405, 530406, 530409, 530410, 435188, 424450, 536 27, 534 15, 552588, 552262, C07K 1528, C07K 1702
Patent
active
051663198
ABSTRACT:
This invention provides a method of preparing conjugates of bioactive compounds and site-specific compounds in which covalent bonding between the compounds is effected by interfacial condensation while protecting the active binding sites from the condensation reaction. This provides very high yields of the bioactive, site-specific conjugate, the products are homogeneous and it provides novel conjugate products. It is of particular advantage for monoclonal antibodies conjugated with cytotoxic agents.
REFERENCES:
patent: 3959079 (1976-05-01), Mareschi et al.
patent: 4066504 (1978-01-01), Krasnobajew et al.
patent: 4522750 (1985-06-01), Ades et al.
patent: 4671958 (1989-06-01), Redwell et al.
patent: 4699784 (1987-10-01), Shih et al.
patent: 4775714 (1988-10-01), Hermann et al.
patent: 4843147 (1989-06-01), Levy et al.
patent: 4883864 (1989-11-01), Scholz
Blair et al. (1983), J. Immunol. Methods 59:129-143.
Lowell et al. (1988), J. Expt. Medicine 167:658-663.
Brunswick Corporation
Kim Kay K.
Nucker Christine M.
LandOfFree
Interfacial condensation of bioactive compounds and the site-spe does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Interfacial condensation of bioactive compounds and the site-spe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interfacial condensation of bioactive compounds and the site-spe will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-922698