Interface for coupling liquid chromatography to solid or gas pha

Details Interface for coupling liquid chromatography to solid or gas pha Interface for coupling liquid chromatography to solid or gas pha

1989-11-22

1990-09-25

Raevis, Robert

Measuring and testing

Sampler, sample handling, etc.

Analyzer supplier

250288, G01N 100

Patent

active

049585290

ABSTRACT:
An improved interface is provided for receiving effluent from a chromatographic device and outputting sample particles of interest to a detector for analysis. The interface includes a gas diffusion cell having a membrane therein separating the cell into an aerosol flow chamber and a sweep gas flow chamber. The effluent is sprayed as an aerosol into the aerosol flow chamber, and vaporized solvent diffuses through the gas membrane into the sweep gas flow chamber while particles of interest are output to the detector. Sweep gas is passed through the sweep gas flow chamber for removing the solvent vapor, and the flow rate of sweep gas is controlled to achieve little or no net flow of gas across the membrane. Efficient solvent removal may be achieved at room temperature for certain LC flow rates, and high detector resolution is possible by maintaining laminar flow of the carrier gas through the aerosol flow chamber.

REFERENCES:
patent: 4112297 (1978-09-01), Miyagi et al.
patent: 4730111 (1988-03-01), Vestal
"Combined Supercritical Fluid Chromatography/Mass Spectrometry (SFC/MS)", Arpino, pp. 1170-1186.
"Supercritical Fluid Chromatography-Mass Spectrometry: A Complementary Technique to GC-MS and LC-MS", Chapman et al, pp. 1188-1189.
"Studies with Packed and Capillary Column Supercritical Fluid Chromatography/Mass Spectrometry", Games et al, pp. 1190-1191.
"Detection of Aerosol Formation in the Effluent of a Supercritical Fluid Chromatography", Goates et al, Analytical Chemistry, vol. 59, No. 24, 12/15/87, pp. 2927-2930.

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