Intercellular adhesion molecules, and their binding ligands

Details Intercellular adhesion molecules, and their binding ligands Intercellular adhesion molecules, and their binding ligands

1990-04-27

1994-02-08

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

53038822, 530395, 530808, 530868, 514 8, A61K 39395

Patent

active

052849317

ABSTRACT:
Pharmaceutical compositions comprising antibodies to intercellular adhesion molecule-1 (ICAM-1 or CD54) are useful in methods of decreasing the severity of inflammation associated with the adhesion of leukocytes to cells bearing ICAM-1. Treatment with anti-ICAM-1 antibodies reduced the severity of inflammation associated with acute organ or tissue rejection and prolonged allograft survival time. Such compositions may optionally contain other immunsuppressive agents.

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Dust
This invention was made in part with Government support. The Government has certain rights in this invention.

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