Intercalating agents specifying nucleotides

Details Intercalating agents specifying nucleotides Intercalating agents specifying nucleotides

1984-06-14

1985-10-15

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 23, 536 27, 536 28, C07H 1910

Patent

active

045475695

ABSTRACT:
This invention discloses a molecule bearing a biologically active group (a phenanthridinium moiety) joined covalently to an oligonucleotide recognition system (a phosphorus nucleoside group) by a linker that permits intercalation of the active group in the pocket formed by the nucleotide and complementary bases in another polynucleotide strand. This class of compounds is illustrated by the following: ##STR1## where R is selected from the group consisting of --NH.sub.2, methylamino, or ethylamino or hydrogen;

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Jacquemin-Sablon, et al., Biochemistry, 18:128, (1979).
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LePecq et al., Proc. Natl. Acad. Sci. USA, 72:2915, (1975).
Dervan et al., J. of the Amer. Chem. Soc., 100:1968-1971, (1978).
Migrdichian, Organic Synthesis, vol. 1, p. 367, Reinhold, (1958).

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