Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-11-21
2006-11-21
Kerr, Kathleen M. (Department: 1656)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S015000, C435S194000, C435S325000, C435S320100, C435S252300, C530S350000, C530S300000
Reexamination Certificate
active
07138236
ABSTRACT:
The interaction of ATM and related protein kinases such as ATR and DNA-PK with p53 is disclosed, in particular the phosphorylation of Ser15 and Thr18 by these proteins. The activity of the proteins is shown to increase in the presence of DNA. Assays for modulators of phosphorylation by the interaction between the proteins and p53 or other proteins having similar phosphorylation sites are provided. Methods of purifying ATM or ATR employing DNA or NTA are also disclosed.
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Jackson Stephen Philip
Lakin Nicholas David
Smith Graeme Cameron Murray
Bozicevic Field & Francis LLP
Kerr Kathleen M.
Kudos Pharmaceuticals Limited
Robinson Hope
Sherwood Pamela J.
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