Interactions between RaF proto-oncogenes and CDC25 phosphatases,

Details Interactions between RaF proto-oncogenes and CDC25 phosphatases, Interactions between RaF proto-oncogenes and CDC25 phosphatases,

1994-10-24

2000-03-14

Wortman, Donna

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 78, 435 15, 435 21, G01N 33573

Patent

active

060371366

ABSTRACT:
The present invention derives from the discovery that CDC25 phosphatases and Raf proteins are able to physically interact to form protein-protein complexes, with the Raf protein mediating the activation of CDC25 phosphatases. The present invention provides both cell-free and cellular assays for detecting agents which modulate the ras-dependent activation of CDC25, as for example, by affecting the binding of a CDC25 protein with Raf, or Raf-associated complexes. Also disclosed is a method for transforming/immortalizing cells, particularly primary cell cultures.

REFERENCES:
patent: 5405941 (1995-04-01), Johnson
patent: 5443962 (1995-08-01), Draetta et al.
patent: 5532167 (1996-07-01), Cantley et al.
Galaktionov et al, Genes and Devel vol. 9:1046-1058, 1995.

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