Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-01-15
1994-10-25
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 514 2, 514 8, 435 1, 424523, A61K 3700, A61K 3710, A01N 102
Patent
active
053589319
ABSTRACT:
A newly discovered property of thermal hysteresis proteins is the interaction of these proteins with cell membranes and thus with cells themselves, protecting cells and their membranes from damage which they would otherwise suffer upon exposure to non-physiological conditions such as temperature abnormalities, including both hyperthermic, hypothermic and sub-freezing temperatures. Improved rates of cell viability are observed over a wide range of conditions which do not involve ice formation, including temperatures above the freezing range as well as temperatures below the freezing range but in vitrification conditions. Heretofore the only known property of these proteins was their ability to interact with ice crystals. In conditions in which ice crystals are formed, it is further discovered that use of the proteins with human cells at the concentrations in which they naturally occur in the source organisms results in aggravating the injury to the cells rather than reducing it, but that the injury is lessened, and the survival rate improved, by using low concentrations. The proteins thus offer benefits in the preservation and improved viability of cell suspensions, tissues and whole organs. The proteins are further discovered to have the ability to block ion channels in mammalian cell membranes, thereby providing a further utility in the treatment of disease conditions.
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Arav Amir
Devries Arthur L.
Rubinsky Boris
Robinson Douglas W.
The Regents of the University of California
Weber Jon P.
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