Interaction of Smad6 with Hox proteins and uses thereof

Details Interaction of Smad6 with Hox proteins and uses thereof Interaction of Smad6 with Hox proteins and uses thereof

2005-11-22

2005-11-22

McGarry, Sean (Department: 1635)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S069100, C435S091100, C536S023100, C536S023500

Reexamination Certificate

active

06967078

ABSTRACT:
The present invention describes a novel interaction between Smad6 and the Hox genes in nuclear transcriptional regulation following BMP signal transduction. The present invention further provides methods of using this novel Smad6/Hox protein interaction to regulate gene expression, regulate bone formation and control osteoporosis. Further provided are methods of screening for compounds that interfere with the novel Smad6/Hox protein interaction, thereby resulting in expression of a Hox protein-repressed gene and/or stimulating bone formation.

REFERENCES:
Hata, A., et al.,Smad6 Inhibits BMP/Smad1 Signaling by Specifically Competing With the Smad4 Tumor Supressor. Genes&Developmentvol. 12, 1998, pp. 186-197.
Ishisaki, A., et al.Differential Inhibition of Smad6 and Smad7 on Bone Morphogenetic Protein and Activin-Mediated Growth Arrest and Apoptosis in B Cells. The Journal of Biological Chemistryvol. 274, 1999, pp. 13637-13642.

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