Interaction of MHC Class II proteins with members of the PCNA fa

Details Interaction of MHC Class II proteins with members of the PCNA fa Interaction of MHC Class II proteins with members of the PCNA fa

1997-03-28

1999-08-10

Cunningham, Thomas M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436501, 530300, 530350, 530395, 435 723, 435 724, G01N 3353

Patent

active

059357975

ABSTRACT:
Present invention based on the identification of the molecular interaction that forms the basis of the immunosuppressive activity of peptides comprising residues 71-80 of an MHC Class II protein (Class II peptides). Specifically the present invention discloses that Class II peptides bind to members of the PCNA family of proteins. Based on this observation, present invention provides methods for identifying agents that can be used to modulate immune system activity.

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