Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1998-01-06
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 721, 435723, 435724, 435375, G01N 3353, C12Q 168
Patent
active
057053421
ABSTRACT:
The invention provides compositions and methods for screening for agents which are modulators of bcl-2 function and can modulate bcl-2-mediated apoptosis and/or modulate neoplastic and immune conditions dependent upon bcl-2 function. The invention also provides a composition comprising a substantially pure protein complex comprising a R-ras polypeptide and a bcl-2 polypeptide.
REFERENCES:
patent: 5550019 (1996-08-01), Reed
Reed et al., Molecular and Cellular Biology, vol. 10, pp. 4370-4374, 1990.
Lowe et al., Cell, vol. 48, pp. 137-146, 1987.
Chien et al., PNAS, vol. 88, pp. 9578-9582, 1991.
Bischoff James R.
Fernandez-Sarabia Maria Jose
Giotta Gregory
Hughes Melya J.
Ketter James
Neeley Richard L.
ONYX Pharmaceuticals, Inc.
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