Inter-phenylene CBA compounds

Details Inter-phenylene CBA compounds Inter-phenylene CBA compounds

1980-12-22

1981-12-15

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260239BF, 26032645, 260465F, 260465D, 2603265C, 544176, 544386, 544336, 544171, 546205, 546309, 546337, 546314, 546203, 546285, 564 80, 564172, 564174, 564 88, 564 90, 564 95, 564158, 562466, 562451, 562452, 562455, 568632, 568633, 568634, 568734, 568807, 568808, C07C17700, C07C 5954

Patent

active

043060765

ABSTRACT:
The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.

REFERENCES:
Derwent Abstract 42718c/24 NL 7908,484 27.05.80.

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