Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-03-21
2006-03-21
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007210, C436S063000, C436S086000, C436S089000, C436S173000, C436S178000, C436S501000, C436S518000, C530S300000, C530S350000, C530S387900
Reexamination Certificate
active
07015004
ABSTRACT:
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer, predict disease risk assessment, and develop therapeutic avenues against the disease.
REFERENCES:
patent: 5062935 (1991-11-01), Schlag et al.
patent: 5766848 (1998-06-01), Borden et al.
patent: 6020208 (2000-02-01), Hutchens et al.
patent: 6329500 (2001-12-01), Webb et al.
patent: 6660482 (2003-12-01), Lim et al.
patent: WO 90/14148 (1990-11-01), None
patent: WO 93/24834 (1993-12-01), None
patent: WO 98/07036 (1998-02-01), None
patent: WO01/63280 (2001-08-01), None
patent: WO01/75454 (2001-10-01), None
patent: WO 02/059604 (2002-08-01), None
Tockman et al. “Consideration in bringing a caner biomarker to clinincal application.” Cancer Research, Suppl. vol. 52, pp. 2711s-2718s, May 1992.
Tascilar et al. Annals of Oncology 10,Suppl. 4:S107-S110, 1999.
Takahashi et al., “Rapid and Sensitive Immunoassay for the Measurement of Serum S100β Using Isoform-specific Monoclonal Antibody”, Clinical Chemistry 45, No. 8, (1999) pp. 1307-1311.
Richter et al., “Composition of the peptide fraction in human blood plasma: database of circulating human peptides”, Journal of Chromatography 8; 726 (1999) pp. 25-35.
Van Cool, “α2-Macroglobulin Expression in Neuritic-Type Plaques in Patients With Alzheimer's Disease”, Neurobiology of Aging (1993) vol. 14, No. 3, pp. 233-237.
Ahmad, et al., “A Study of Plasma Alpha-2-Macroglobulin Levels in Type 2 Diabetic Subjects with Microalbuminuria”, J. Assoc. Physicians of India (2001), vol. 49, pp. 1062-1065.
Sesboue, et al., “Quantitative study of human blood alpha-1-antitrypsin, alpha-2-macroglobulin and inter-alpha-trypsin-inhibitor with respect to plasma renin activity”, Clinica Chimica Acta (1983) vol. 135, No. 1, pp. 23-34.
Database EMB“Online! Teich et al., Alpha-2-macroglobulin (fragment)”, retrieved from EMBL, Database accession No. Q9BQ22, XP-002237293.
C. Bristow et al, “Specific Activity of alpha 1 Proteinase Inhibitor and alpha2Macroglobulin in Human Serum; Application to Insulin-Dependent Diabetes Mellitus”, Clin Immunol Immunopath, 89(3):247-259 (Dec., 1998).
G. Trefz et al, “Establishment of an Enzyme-Linked Immuno-Sorent Assay for Urinary Trypsin Inhibitor by Using a Monoclonal Antibody”, Journal of Immunoassay, 12(3):347-369 (1991).
Y. MA et al, “Transgenic Mice Overexpressing y-aminobutyric Acid Transporter Subtype I Develop Obesity”, Cell Research, 10(4):303-310 (Dec., 2000).
H. Bloeker et al, “Hypothetical Protein”, Database Accession No. Q9H030, XP002249055 (Mar., 2001) Abstract.
T. Nagase et al, “Hypothetical Protein KIAA 1697”, Database Accession No. Q9C0G6, XP002249056 (Jun., 2001) Abstract.
Jackowski George
Marshall John
Cook Lisa V
Le Long V.
McHale & Slavin P.A.
Syn X Pharma, Inc.
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