Intelligent system and method for automated packing of...

Liquid purification or separation – Processes – Chromatography

Reexamination Certificate

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Details

C210S198200

Reexamination Certificate

active

07435350

ABSTRACT:
The present invention provides an automated system and method for packing chromatography columns. In one embodiment, the system first determines the type of media that is present in the column, and uses this information to generate an automated procedure to pack the specific media type. In a second embodiment, the media type is made known to the system, such as via input from the operator. The system then uses this information, in the same manner as in the first embodiment, to generate an automated procedure to pack the specific media type. Finally, in a third embodiment, parameters such as column height and rate of compression are made known to the system, such as via input from the operator. The system then packs the column in accordance with these supplied parameters.

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patent: 2004/0099604 (2004-05-01), Hauck et al.
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The European Search Report dated Oct. 8, 2007.
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Journal of Chromatography A, 741 (1996) 175-184; “Consolidation of the packing material in chromatographic columns under dynamic axial compression IV. Mechanical Properties of some packing materials” Brett J. Stanley et al.
Journal of Chromatography A., 989 (2003) 79-94; Martin Hofmann; “Use of ultrasound to monitor the packing of large-scale columns, the monitoring of media compression and the passage of molecules, such as monoclonal antibodies, through the column bed during chromatography”.
European Search Report dated Jul. 31, 2006.
Columns for Chromatography In Industrial Purification and Laboratory Use; Amicon a Grace company; Publication No. 531.
MicroPatent Search EP0008921; Column Chromatography and Like Processes and Apparatus for the Practice Thereof; Wright Scientific Limited.
Moduline Industrial Chromatography Column Operating Instructions; Publication No. Amicon a Grace company (cover page and last page The Moduline Industrial Chromatograph Column Operating Instructions consists of a cover page and a final page with Amicon contact information on it.

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