Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-04
2007-09-04
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S427000, C548S439000, C548S440000, C548S444000, C548S530000, C548S537000, C548S538000, C514S408000, C514S423000
Reexamination Certificate
active
11111105
ABSTRACT:
Provided are compounds of formula (I)wherein A, Q, W, X, Y, Z, R1to R4, m and n are as defined herein. Compounds of the invention bind to α4integrin receptors and thereby inhibit binding of ligands for α4integrins which is useful for prophylactic and/or therapeutic treatment of diseases and conditions associated with α4integrins or their ligands.
REFERENCES:
patent: 5079260 (1992-01-01), Weitzberg et al.
patent: 5223517 (1993-06-01), Muller et al.
patent: 5272161 (1993-12-01), Niewohner et al.
patent: 5334606 (1994-08-01), MacLeod
patent: 5519043 (1996-05-01), Perumattam
patent: 5773465 (1998-06-01), Gandolfi et al.
patent: 5773646 (1998-06-01), Chandrakumar et al.
patent: 5891899 (1999-04-01), Clark et al.
patent: 5908863 (1999-06-01), Allegretti et al.
patent: 5994351 (1999-11-01), Robinson et al.
patent: 6706753 (2004-03-01), Artis et al.
patent: 6933314 (2005-08-01), Artis et al.
patent: 327877 (1989-08-01), None
patent: 48054061 (1973-07-01), None
patent: WO97/01540 (1997-01-01), None
patent: WO99/10312 (1999-03-01), None
Andrew, H. F., et al., “Nitration of 3-Methylfluoranthene”J. Chem. Soc., Perkins Trans. 1 vol. 6:755-759 (1972).
Butcher et al., “Lymphocyte Homing and Homeostasis”Science272:60-66 (1996).
Cardarelli et al., “Cyclic RGD Peptide Inhibits α4β1 Interaction with Connecting Segment 1 and Vascular Cell Adhesion Molecule”Journal of Biological Chemistry269:18668-18673 (1994).
Chuluyan et al., “α4—Integrin-dependent emigration of monocytes”Springer Semin. Immunopathology16:391-404 (1995).
Database Crossfire Beilstein ‘Online’, Beilstein Institut zur Forderung der Chemischen Wissenschafte, Frankfurt am Main, DE; Database accession No. 2187180 XP002194815 Abstract; & Campell, Crombie: Proc. Royal Soc. London, Series A, Mathematical & Physical Sciences, 65:376 (1960-1961) Royal Society of.
Elices et al., “VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site”Cell60:577-584 (1990).
Fotouhi et al., “Cyclic Thioether Peptide Mimetics as VCAM-VLA-4 Antagonists”Bioorganic&Medicine Chemistry Letters10:1167-1169 (2000).
Hamilton, et al., “Fluorenylalkanoic and Benzoic Acids as Novel Inhibitors of Cell Adhesion Processes in Leukocytes”J. Med. Chem.38:1650-1656 (1995).
Hemler, “VLA proteins in the integrin family: structures, functions, and their role on leukocytes”Annu. Rev. Immunol.8:365-400 (1990).
Hynes, “Integrins: versatility, modulation, and signaling in cell adhesion”Cell69(1) :11-25 (1992).
Jackson et al., “Potent α4β1 Peptide Antagonists as Anti-Inflammatory Agents”Journal of Medicinal Chemistry40 (21) :3359-3368 (Oct. 10, 1997).
Juliano et al., “Adhesion molecules in cancer: the role of integrins”Current Opinion Cell Biology5:812-818 (1993).
Laberge, S. et al., “Role of VLA-4 and LFA-1 in Allergen-Induced Airway Hyperrespnosiveness and Lung Inflammation in the Rat”Am. J. Respir. Crit. Care Med.151:822-829 (1995).
Makarem et al., “Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin α4β1”Journal of Biological Chemistry269:4005-4011 (1994).
Nakajima et al., “Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen—induced eosinophil and T cell recruitment into the tissue”Journal of Experimental Medicine.
Sharar et al., “The adhesion cascade and anti-adhesion therapy: an overview”Springer Semin. Immunopathology16:359-378 (1995).
Simmons et al., “Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells”Blood80:388-395 (1992).
Artis Dean R.
Jackson David Y.
Rawson Thomas E.
Reynolds Mark E.
Stanley Mark S.
Evans David W
Genentech Inc.
Shameem Golam M. M.
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