Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-12-20
1998-06-02
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544238, 544262, 544350, 544 67, 544224, 544333, 544295, 544337, 544371, 544361, 544 96, 544 98, 544182, 544179, 546119, 546244, 5462781, 5462681, 5462724, 5483611, 548122, 548127, 548128, 548131, 548134, 548136, 548146, 548254, 548255, 5482622, 5483121, 540545, 540554, 540575, 540596, 540597, 540598, 540599, 540600, 540601, 540602, 540603, 514212, 5142282, 5142292, 514227, 514253, 514256, 514258, 514242, C07D40314, C07D40114, A61K 3154, A61K 31535
Patent
active
057600287
ABSTRACT:
This invention relates to novel heterocycles including xycarbonylamino)propionic acid, which are useful as antagonists of the .alpha..sub.v .beta..sub.3 integrin and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.
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patent: 5444038 (1995-08-01), James et al.
Batt Douglas Guy
Jadhav Prabhakar Kondaji
Petraitis Joseph James
Ferguson Blair Q.
Grumbling Matthew V.
The DuPont Merck Pharmaceutical Company
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