Integrin-linked kinase and its uses

Details Integrin-linked kinase and its uses Integrin-linked kinase and its uses

1997-10-21

2000-01-11

Campell, Bruce R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 4353201, 435325, 435 701, C07H 2102, C12N 1500, C12P 2104

Patent

active

060137827

ABSTRACT:
Methods for isolating ILK genes are provided. The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

REFERENCES:
V.G. Pursel et al. J. Reprod. Fert., Suppl. 40, 235-245, 1990.
Catherine A. Kappel et al. Current Opinion in Biotechnology, 3:548-553, 1992.
L. Hillier et al. GenBank H70160 and R91874, Oct. 1995.
Palmiter et al., Science 222:809-814, Nov. 1983.
X. Jacq et al. Cell 79 (1), 107-117, 1994.
86.sup.th Annual Meeting of the American Association for Cancer Research, Mar. 1995 p. 361, XP000673939, Hannigan et al. "Cloning of a novel protein kinase associated with beta 1 integrin cytoplasmic tails".
Molecular Biology of the Cell, vol. 6, supl. Nov. 1995 p. 2244 XP000673935, Hannigan et al., "Overexpression of a novel integrin linked kinase (ILK) induces a transformed phenotype and cyclin D1 expression".
Morino et al. (1995) J. Biological Chemistry 270:269-273, "Matrix-integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2".
Genbank accession No. H70160.
Dedhar and Hannigan (1996) Curr. Opin. Cell Bio. 8:657-559, "Integrin cytoplasmic interactions and bidirectional transmembrane signalling".
Hannigan et al. (1996) Nature 379:91-96, Regulation of Cell Adhesion and Anchorage Dependent growth by a new beta 1-integrin linked protein kinase.

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