Integrin-linked kinase and its use

Details Integrin-linked kinase and its use Integrin-linked kinase and its use

1998-03-05

1999-12-14

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 15, C12N 912, C12Q 148

Patent

active

060016221

ABSTRACT:
Methods for isolating ILK genes are provided. The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

REFERENCES:
Dedhar, Shoukat, "Integrin Mediated Signal Transduction In Onocogenesis: An Overview," Cancer and Metasis Reviews (1995) vol. 14:165-172.
Lin, Tsung H. et al., "Integrin-Mediated Tyrosine Phosphorylation and Cytokine Message Induction In Monocytic Cells," The Journal of Biological Chemistry (Jul. 7, 1995) vol. 270, No. (27):16189-16197.
Miyamoto, Shingo et al., "Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function," Science (Feb. 10, 1995) vol. 267:883-885.
Rosales, Carlos et al., "Signal Transduction By Cell Adhesion Receptors," Biochemica et Biophysica Acta (1995) vol. 1242:77-98.

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