Integrin-binding peptides

Details Integrin-binding peptides Integrin-binding peptides

2006-06-27

2006-06-27

Gupta, Anish (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C530S328000, C530S329000

Reexamination Certificate

active

07067619

ABSTRACT:
This invention is directed to novel integrin binding peptides. These peptides bind to αv- of α5-containing integrins and can exhibit high binding affinity. They contain one of the following sequence motifs: RX1ETX2WX3[SEQ ID NO:1] (especially RRETAWA [SEQ ID NO:8]); RGDGX [SEQ ID NO:2], in which X is an amino acid with a hydrophobic, aromatic side chain; the double cyclic CX1CRGDCX2C [SEQ ID NO:15]; and RLD. The peptides generally exhibit their highest binding affinity when they assume a conformationally stabilized configuration. This invention also provides methods of using these peptides.

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