Integrin-binding peptides

Details Integrin-binding peptides Integrin-binding peptides

1995-04-18

1997-05-06

Weimar, Elizabeth C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530328, A61K 3804, C07K 706, C07K 708

Patent

active

056272634

ABSTRACT:
The present invention provides peptides having specificity for fibronectin-binding and vitronectin-binding integrins, and in particular for .alpha..sub.5 .beta..sub.1 integrin. These peptides are characterized by having the ability to interfere with fibronectin binding to .alpha..sub.5 .beta..sub.1 integrin, to block attachment of cells expressing integrins to extracellular matrix proteins and to promote cell attachment when immobilized onto a surface.

REFERENCES:
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Koivunen, Erkki et al., "Isolation of a Highly Specific Ligand for the .beta..sub.5 .beta..sub.1 Integrin from a Phage Display Library." J. Cell Biol. 124:373-380 (1994).
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Pierschbacher, Michael D. and Ruoslahti, Erkki, "Influence of Sterochemistry of the Sequence Arg-Gly-Asp-Xaa on Binding Specificity in Cell Adhesion." J. Biol. Chem. 262:17294-17298 (1987).
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