Integrin-binding peptides

Details Integrin-binding peptides Integrin-binding peptides

1994-03-11

1996-07-16

Grimes, Eric

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530317, 530328, C07K 706, C07K 764

Patent

active

055368140

ABSTRACT:
The present invention provides peptides having specificity for fibronectin-binding and vitronectin-binding integrins, and in particular for .alpha..sub.5 .beta..sub.1 integrin. These peptides are characterized by having the ability to interfere with extracellular matrix protein binding to integrins; to block attachment of cells expressing these integrins to extracellular matrix proteins; and to promote cell attachment when coated onto a surface.

REFERENCES:
patent: 5192746 (1993-03-01), Lobl et al.
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