Integrin-binding peptides

Details Integrin-binding peptides Integrin-binding peptides

1994-08-04

1999-11-09

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 514 14, 514 15, 514 16, 530317, 530327, 530328, 530329, A61K 3812, C07K 512

Patent

active

059814780

ABSTRACT:
This invention is directed to novel integrin binding peptides. These peptides bind to .alpha..sub.v - of .alpha..sub.5 -containing integrins and can exhibit high binding affinity. They contain one of the following sequence motifs: RX.sub.1 ETX.sub.2 WX.sub.3 [SEQ ID NO: 1] (especially RRETAWA [SEQ ID NO: 8]); RGDGX [SEQ ID NO: 2], in which X is an amino acid with a hydrophobic, aromatic side chain; the double cyclic CX.sub.1 CRGDCX.sub.2 C [SEQ ID NO: 15]; and RLD. The peptides generally exhibit their highest binding affinity when they assume a conformationally stabilized configuration. This invention also provides methods of using these peptides.

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