Integrin-binding peptides

Details Integrin-binding peptides Integrin-binding peptides

1996-04-03

1999-06-15

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 18, 514 16, 514 14, 514 13, A61K 3800

Patent

active

059122340

ABSTRACT:
The present invention provides peptides having specificity for fibronectin-binding and vitronectin-binding integrins, and in particular for .alpha..sub.5 .beta..sub.1 integrin. These peptides are characterized by having the ability to interfere with extracellular matrix protein binding to integrins; to block attachment of cells expressing these integrins to extracellular matrix proteins; and to promote cell attachment when coated onto a surface.

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