Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Reexamination Certificate
2011-08-16
2011-08-16
Haddad, Maher (Department: 1644)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
C530S387100, C530S388100, C530S388220
Reexamination Certificate
active
07998738
ABSTRACT:
Ligand-mimetic monoclonal antibody mAb 107, produced by a hybridoma cell line deposited in the American Type Culture Collection under Accession Number ATCC PTA-11614, which binds to CD11b MIDAS in an activation-independent manner.
REFERENCES:
patent: 5985278 (1999-11-01), Mitjans et al.
patent: 7064180 (2006-06-01), Arnaout et al.
patent: 7323552 (2008-01-01), Arnaout et al.
patent: 2003/0078375 (2003-04-01), Arnaout et al.
patent: WO00/59878 (2000-10-01), None
patent: WO00/60355 (2000-10-01), None
patent: WO02/04521 (2002-01-01), None
patent: WO02/09737 (2002-02-01), None
patent: WO02/31511 (2002-04-01), None
Rieu et al. The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF.. J Cell Biol. Dec. 1994;127(6 Pt 2):2081-91.
Li et al., The Journal of Immunology, 2002;168;1219-1225.
Baldwin et al., “Cation binding to the integrin CD11b I domain and activation model assessment”,Structure, 6:923-935 (1998).
Burgess et al., “Possible dissociation of the Heparin-Binding and Mitogenic Activities” J. Cell Biol III: 2129-2138 (1990).
Edwards et al., “Mapping the Intercellular Adhesion Molecule-1 and—2 Binding Site on the Inserted Domain of Leukocyte Function-associated Antigen-1”,The Journal of Biological Chemistry, 273:28937-28944 (1998).
Emsley et al., “Structural Basis of Collagen Recognition by Integrin α2β1”,Cell, 100:47-56 (2000).
Emsley et al., “Crystal Structure of the I Domain from Integrin α2β1”,The Jounal of Biological Chemistry, 272:28512-28517 (1997).
Feng et al., “Peptides Derived from the Complementarity-determining Regions of Anti-Mac-1 Antibodies Block Intercellular Adhesion Molecule-1 Interaction with Mac-1”,The Jounal of Biological Chemistry, 273:5625-5630 (1998).
Kamata T and Takada Y, “Direct Binding of Collagen to the I Domain of Integrin α2β1 (VLA-2, CD49b/CD29) in a Divalent Cation-independent Manner”,The Journal of Biolocal Chemistry, 269:26006-26010 (1994).
Huth et al., “NMR and Mutagenesis Evidence for and I Domain Allosteric Site . . . ”Proc. Nat'l. Acad. Sci. 97(10):5235, 2000.
Kern et al., “The Role of the I Domain in Ligand Binding of the Human Integrin α1β1”,The Journal of Biological Chemistry, 269:22811-22816 (1994).
Lazar et al., “Transforming Growth Factor Alpha . . . ” Mol. Cell. Biol. 8:1247-1252 (1988).
Lee et al., “Crystal Structure of the A Domain from the α Subunit of Integrin CR3 (CD11b/CD18)”Cell, 80:631-638 (1995).
Lee et al., “Two conformations of the integrin A-domain (I-domain): a pathway for activation?”,Structure, 3:1333-1340 (1995).
Legge et al., “NMR Solution Structure of the Inserted Domain of Human Leukocyte Function Associated Antigen-1”,Journal of Molecular Biology, 295:1251-1264 (2000).
Li et al., “Two Functional States of the CD11b A-Domain: Correlations with Key Features of Two Mn2+—complexed Crystal Structures”,The Journal of Cell Biology, 143:1523-1534 (1998).
Michishita et al., “A Novel Divalent Cation-Binding Site in the A Domain of the β2 Integrin CR3 (CD1 1b/CD18) Is Essential for Ligand Binding”,Cell, 72:857-867 (1993).
Nolte et al., “Crystal structure of the α1β1 integrin I-domain: insights into Integrin I-domain function”,FEBS Letters, 452:379-385 (1999).
Oxvig et al., “Conformational changes in tertiary structure near the ligand binding site of an integrin I domain”,Proc. Natl. Acad. Sci. USA, 96:2215-2220 (1999).
Rieu et al., “Solvent-accessible Residues on the Metal Ion-dependent Adhesion Site Face on Integrin CR3 Mediate Its binding to the Netrophil Inhibitory Factor”,The Journal of Biological Chemistry,271:15858-15861 (1996).
Smith JW and Cheresh DA, “The Arg-Cly-Asp Binding Domain of the Vitronectin Receptor”,The Journal of Biological Chemistry, 263:18726-18731 (1988).
Xiong et al., “An Isoleucine-based Allosteric Switch Controls Affinity . . . ” J. of Biol. Chem. 275:38762-38767, 2000.
Zhang L and Plow EF, “A Discrete Site Modulates Activation of I Domains”,The Journal of Biological Chemistry, 271:29953-29957 (1996).
Zhang L and Plow EF, “Amino Acid Sequences within the αSubunit of Integrin αMβ2(Mac-1) Critical for Specific Recognition of C3bi”,Biochemistry, 38:8064-8071 (1999).
Fish & Richardson P.C.
Haddad Maher
The General Hospital Corporation
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