Integrin .beta. subunit and uses thereof

Details Integrin .beta. subunit and uses thereof Integrin .beta. subunit and uses thereof

1991-07-11

1999-10-05

Spector, Lorraine

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 14435

Patent

active

059626437

ABSTRACT:
The present invention provides substantially pure integrins containing a novel .beta. subunit designated as .beta..sub.6. The novel .beta..sub.6 subunit forms heterodimers with .alpha..sub.V and .alpha..sub.F. Methods of controlling cell adhesion using the B.sub.6 -containing integrins are also provided.

REFERENCES:
Kajiji et al., EMBO J. 8:673-680 (1989).
Cheresh et al., Cell 57:59-69 (1989).
Freed et al., EMBO J. 8:2955-2965 (1989).
Holzmann et al., Cell 56:37-46 (1989).
Ramaswamy et al "Cloning, Primary Structure and Properties of a Novel Integrin .beta. Subunit" EMBO 9 (5) pp. 1561-1568 (May 1990).
Sheppard et al "Complete Amino Acid Sequence of a Novel Integrin .beta. . . . " J. Biological Chemistry 265 (20) pp. 11502-11507 (Jul. 15, 1990).

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