Integrated sample analysis device

Details Integrated sample analysis device Integrated sample analysis device

2005-12-27

2005-12-27

Marschel, Ardin H. (Department: 1631)

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

C422S068100, C422S129000, C435S004000, C435S006120, C435S007100

Reexamination Certificate

active

06979424

ABSTRACT:
An analysis device comprises a body having a reaction chamber for chemically reacting a sample, a separation region for separating components of the sample, and a transition region connecting the reaction chamber to the separation region. The transition region includes at least one valve for controlling the flow of fluid between the reaction chamber and the separation region. Further, the transition region thermally isolates the reaction chamber from the separation region. In a preferred embodiment, the reaction chamber is an amplification chamber for amplifying nucleic acid in the sample, and the separation region comprises an electrophoresis channel containing a suitable matrix material, such as electrophoresis gel or buffer, for separating nucleic acid fragments. Electrodes are embedded in the body for separation of sample components. The body may also be surrounded by external, functional components such as an optical detector for detecting separated components of the sample.

REFERENCES:
patent: 5480614 (1996-01-01), Kamahori
patent: 5587128 (1996-12-01), Wilding et al.
patent: 5589136 (1996-12-01), Northrup et al.
patent: 5646039 (1997-07-01), Northrup et al.
patent: 5744366 (1998-04-01), Kricka et al.
patent: 5824204 (1998-10-01), Jerman
patent: 5849208 (1998-12-01), Hayes et al.
patent: 5856174 (1999-01-01), Lipshutz et al.
patent: 6074827 (2000-06-01), Nelson et al.
Waters et al., “Microchip Device for Cell Lysis, Multiplex PCR Amplification, and Electrophoretic Sizing”,Anal. Chem.1998, 70, 158-162.
Woolley et al., “Functional Integration of PCR Amplification and Capillary Electrophoresis in a Microfabricated DNA Analysis Device”,Anal. Chem.1996, 68, 4081-4086.
Webster et al., “Large-Volume Integrated Capillary Electrophoresis Stage Fabricated Using Micromachining of Plastics on Silicon Substrates”,International Conference on Solid-State Sensors and Actuators(Transducers '97) (Chicago) pp. 503-506, 1997.

Affiliated with

Also associated with

Rating

Integrated sample analysis device does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Integrated sample analysis device, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Integrated sample analysis device will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3518026