Integrated optical compensating refractometer apparatus

Optics: measuring and testing – By polarized light examination – With birefringent element

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356128, 356345, 356133, 385 12, G01B 902

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active

053770080

ABSTRACT:
An apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a compensation path that includes the sensing region to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. In one embodiment a ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a curved or serpentine path configured so that nonspecific sensing effects are compensated.

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