Integrated microfluidic transport and sorting system

Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07658829

ABSTRACT:
The invention integrates a two-stage dielectrophoretic (DEP) droplet dispensing and distribution system with particulate DEP to create a novel LOC platform capable of manipulating biological cells based on the varied dielectrophoretic signatures that distinguish cells in a population, for example, healthy from diseased cells. The two-stage DEP droplet transport system acts as the backbone of this application, providing the essential dispensing and distribution function, while particulate DEP provides the critical capability to characterize and analyze the heterogeneous biological cell populations routinely encountered in biotechnology and clinical settings.

REFERENCES:
patent: 4390403 (1983-06-01), Batchelder
patent: 7255780 (2007-08-01), Shenderov
patent: 2003/0173223 (2003-09-01), Gascoyne et al.
Youlan, L., et al., “Dielectrophoretic fluidic cell fractionation system,” Analytice Chimica Acta, Apr. 1 2004, pp. 151-161, v507.
Hughes, M.P., “AC electrokinetics: applications for nanotechnology”, Nanotechnology, Jun 2000, pp. 124-132, v11.
Pethig, R., Markx, G.H., “Applications of dielectrophoresis in biotechnology”, Trends Biotech., Oct. 1997, pp. 426-432, v15.
Wang X., Huang, Y., Gascoyne, P.R.C., Becker, F.F. “Dielectrophoretic Manipulation of Particles”, IEEE Trans, Ind. Appl. May/Jun. 1997. pp. 660-669, v33.
Chan, K.L., Morgan, H., Morgan, E., Cameron, I.T., Thomas, M.R., “Measurements of the dielectric . . . etc.”, Biochim. Biophys. Acta, Mar. 17, 2000, pp. 313-322, v1500.
Gascoyne, P.R.C., Huang, Y., Pethig, R., Vykoukal, J., Becker, F.F., “Dielectrophoretic Separation . . . etc.”, Meas. Sci. Technol., May 1992 pp. 439-445, v3.
Gascoyne, P.R.C., Wang, X., Huang, Y., Becker, F.F., “Dielectrophoretc separation . . . etc.”, IEEE Trans. Ind. Appl., May/Jun. 1997, pp. 670-678, v33.
Green, N. G., Morgan, H., “Separation of submicrometer . . . etc.”, J. Phys. D: Appl. Phys., Apr. 7, 1998, pp. L25-L30, v31.
Becker, F.F., Wang, X., Huang, Y., Pethig, R., Vykoukal, J., Gascoyne, P.R.C., “Separation of human . . . etc.”, Proc, Natl. Acad. Sci. U.S.A., Jan. 1995, pp. 860-864, v92.
Wang, X., Vykoukal, J., Becker, F.F., Gascoyne, P.R.C., “Separation of Polystyrene . . . etc. ”, Biophy. J., May 1998, pp. 2689-2701, v74.
Wang, X., Yang, J., Huang, Y., Vykoukal, J., Becker, F.F., Gascoyne, P.R.C., “Cell Separation . . . etc,”, Anal. Chem., Feb. 15, 2000, pp. 832-839, v72.
Talary, M.S., Burt, J.P.H., Tame, J.A., Pethig, R., “Electromanipulation and Separation . . . etc.”, J. Phys. D: Appl. Phys., Aug. 14, 1996, pp. 2198-2203, v29.
Morgan, H., Green, N.G., Hughes, M.P., Monaghan, W., Tan, T.C., “Large area travelling . . . etc.”, J. Micromech. Microeng., Jun. 1997, pp. 65-70, v7.
Fiedler, S., Shirley, S.G., Schnelle, T., Fuhr, G., “Dielectrophoretic sorting . . . etc.”, Anal. Chem., May 1, 1998, pp. 1909-1915, v70.
Jones, T.B., GUNJI, M., Washizu, M., Feldman, M.J., “Dielectrophoretic liquid actuation and nanodroplet formation”, J. Applied Physics, Jan. 15, 2001, pp. 1-8, v89(3).
Schasfoort, R.B.M., Schlautmann, S., Hendrikse, J., and Van Dan Berg, A., “Field Effect Flow Control . . . etc.”, Science, Oct. 26, 1999, pp. 942-945, v286.
Stroock, A.D., Weck. M.D., Chin, T., Chiu, W.T.S., Huck, T.S.P., Kenis, J.A., Ismagilov, R.F., Whitesides, G.M., Phys. Rev. Lett., Apr. 10, 2000, pp. 3314-3317, v84.
Gallardo, B.S., Gupta, V.K., Eagerton, F.D., Jong, L.I., Craig, V.S., Shah, R.R., and Abbott, N.L., “Electrochemical Principles . . . etc.”, Science, Jan. 1, 1999, pp. 57-60, v283.
Washizu, M., “Electrostatic Actuation of Liquid Droplets for Microreactor Applications”, IEEE Trans. Ind. Appl. Jul./Aug. 1998, pp. 732-737, v34.
Jones, T.B., Gunji M., and Washizu, M., “Dielectrophoretic microfluidic devices,” Proc. of IEJ/ESA Joint Symposium on Electrostatics, Sep. 2000, pp. 78-87.
Yogi, O., Kawakami, T., Mizuno, A., “On-Demand Mixing Droplet Spotter for Preparing Picoliter Droplets on Surfaces”, Anal. Chem., Jun. 1, 2004, pp. 2991-2996, v76(11).
Jones, T.B., “Electrostatics and Lab on a chip”, Institute of Physics Congress, Mar. 2003, Edinburgh.
Jones, T.B., “Liquid dielectrophoresis on the microscale”, Electrostatics, May 2001, pp. 290-299, v51-52.
Fuhr, G., Shirley, S.G., “Cell Handling and Characterization”, J. Micromech. Microeng., Jun. 1995, pp. 77-85, v5.
Hughes, M.P., Morgan, H., “Dielectrophoretic Trapping . . . etc.”, J. Phys. D: Appl. Phys., Sep. 1998, pp. 2205-2210, v31.
Sano, H, Kabata, H., Kurosawa, O., Washizu, M., “Dielectropho . . . etc.”, Technical Digest (IEEE) 15th Int'l Conf. on Microelectromechanical Systems, Jan. 20-24, 2002, pp. 11-14.
Ahmed, R., Hsu, D., Bailey, C., Jones, T.B., “Dispensing Picoliter Droplets, etc.”, Microscale Thermophysical Engineering, Jul./Sep. 2004, pp. 271-283, v8.
Ahmed, R., Jones, T. B., “Dispensing picoliter droplets on substrates using dielectrophoresis,” J. Electrostatics, Jul. 2006, pp. 543-549, v64.
King, M.R., Lomakin, O.A., Ahmed, R., Jones, T., “Size-Selective Deposition . . . etc.”, Journal of applied physics, Feb. 1, 2005, 054902, vol. 97.
Weigl, B. H., Bardell, R.L., Cabrera, C.R., “Lab-on-a-chip . . . etc.”, Adv. Drug Delivery Rev., Feb. 24, 2003, pp. 349-377, v55.
Lee, J., Moon, H., Fowler, J., Schoellhammer, T., Kim, C.-J., “Electrowetting and . . . etc.”, Sens. Actuators A, Jan. 1, 2002, pp. 259-268, vA95.
Yang, J., Huang, Y., Wang, X.B., Becker, F.F., Gascoyne, P.R., “Differential Analysis . . . etc..”, Biophys. J., May 2000, pp. 2680-2689, v78.
Ahmed R., and Jones, T.B., “Dispensing Picoliter . . . etc.”, 5th International Electrohydrodynamics Workshop, Sep. 2004, pp. 283-288, Poitiers, France.
Kaler, K.V.I.S., and Pohl, H.A., “Dynamic Dielectrophoretic Levitation, etc.”, IEEE Trans. Ind. Apps., Nov./Dec. 1983, pp. 1089-1093. v1A-19.
Pethig, R., Huang, Y,, Wang, X.B., Burt, J.P.H., “Positive and negative electrophoretic . . . etc.”, J. Phys. D: Appl. Phys., Jun. 14, 1992, pp. 881-888., v24.
Lee, J., Kim, C.-J., “Microactuation by Continuous Electrowetting Phenomenon . . . etc. ”, ASME Int. Mechanical Engineering Congress and Exposition, Nov. 1998, p. 475, Anaheim, CA.
Shapiro, B., Moon, H., Garrell, R. L., Kim, C.-J., “Equilibrium behavior of sessile drops under . . . etc.”, Journal of Applied Physics, May 1, 2003, p5794, v93.
Vallet, M., Berge, B., Vovelle, L., “Limited Phenomena for the spreading . . . etc.”, The European Physical Journal B, Oct. 1999, pp. 583-591, v11.
Vallet, M., Berge, B., Vovelle, L., “Electrowetting of water and aqueous . . . etc”, Polymer, Jun. 1996, pp. 2465-2470, v37.
Zeng, J., Korsmeyer, T., “Liquid Disintegration: Investigation . . . etc.”, Nanotech 2004 Conference Proceedings, Mar. 7-11, 2004, Cambridge, MA.
Tombak, A., et. al, “Tunable Barium Strontium Titanate Thin Film . . . etc.”, IEEE Microwave and wireless components letters, Jan. 2002, pp. 3-5, v12.
Gascoyne, P.R.C., et. al, “Dielectrophoresis-based programmable fluidic processors”, Jul. 2004, pp. 299-309, v4.
Kaler, K., “Nanotechnology and Medical Devices”, Western Canada Technology Study Tour, Oct. 26, 2004, Powerpoint Presentation.
Kanagasabapathi, T., et al., “Dielectrophoresis (DEP) of cells and microparticles in PDMS microfluidic channels”, Proc. Nanotech Mar. 2004, pp. 81-84, (1-2).
CUI, L., et al., “The dielectrophoretic levitation and separation of latex beads in microchips.”, Electrophoresis, Oct. 2001, pp. 3893-3901, v22.
Gascoyne, P., et al., “Particle separation by Dielectrophoresis. ”, Electrophoresis, Jul. 13, 2002,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Integrated microfluidic transport and sorting system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Integrated microfluidic transport and sorting system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Integrated microfluidic transport and sorting system will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4229432

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.