X-ray or gamma ray systems or devices – Specific application – Diffraction – reflection – or scattering analysis
Reexamination Certificate
2007-09-25
2007-09-25
Glick, Edward J. (Department: 2882)
X-ray or gamma ray systems or devices
Specific application
Diffraction, reflection, or scattering analysis
C378S079000, C378S081000
Reexamination Certificate
active
11064357
ABSTRACT:
A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.
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Garman et al., “Macromolecular Cryocrystallography”, Journal of Applied Crystallography, 1997, vol. 30, pp. 211-237.
Cork Carl W.
Cornell Earl W.
Earnest Thomas N.
Jaklevich Joseph M.
Kolbe William F.
Glick Edward J.
Kao Chih-Cheng Glen
Lawrence Berkeley National Laboratory
Milner Joseph R.
The Regents of the University of California
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