Integrated circuit for a chemical-selective sensor with voltage

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357 41, 357 48, H01L 2704

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047439548

ABSTRACT:
An integrated circuit for a miniaturized solid-state chemical sensor. The integrated circuit includes a chemical-selective membrane which provides an electric signal in response to contact with a particular chemical or group of chemicals in a fluid. The chemical-selective membrane is attached to the integrated circuit by a membrane definition layer. An electrically conductive layer beneath the membrane definition layer provides electrical contact between the chemical-selective membrane and one of the input transistors of the voltage-follower amplifier. The chemical-selective membrane is formed separately from the gate of the input transistors and is designed as a integrated input to the amplifier. The output of the chemical sensor is a low impedance electric signal represented as a voltage which corresponds to the chemical activity present at the chemical-selective membrane/fluid interface. In one embodiment, multiple chemical sensors are fabricated on a single integrated circuit wherein each chemical-selective sensor forms an integrated input to a separate amplifier. Included on the integrated circuit of that embodiment is circuitry to allow for multiplexing of the outputs of the amplifiers to one or both of two output pads provided on the integrated circuit.

REFERENCES:
patent: 4020830 (1977-05-01), Johnson et al.
patent: 4133735 (1979-01-01), Afromowitz et al.
patent: 4332658 (1982-06-01), Tsuboshima
patent: 4385274 (1983-05-01), Shimada et al.
patent: 4411741 (1983-10-01), Janata
patent: 4437969 (1984-03-01), Covington et al.
patent: 4508613 (1985-04-01), Busta et al.
Lauks et al, IEEE International Conf. on Solid State Sensors and Actuators, (Jun. 10, 1985), pp. 122-124.
Ammann et al., "Neutral Carrier Based Hydrogen Ion Selective Microelectrode for Extra- and Intracellular Studies," Analytical Chemistry, vol. 53, pp. 2267-2269.
Bergveld, P., "Development of an Ion-Sensitive Solid-State Device for Neuro-Physiological Measurements," I.E.E.E. Transactions on Bio-Medical Engineering, vol. BME-17, pp. 70-71, Jan. 1970.
Bergveld, P., "Development, Operation, and Application of the Ion-Sensitive Field-Effect Transistor as a Tool for Electrophysiology," I.E.E.E. Transactions on Biomedical Engineering, Vo. BME-19, pp. 342-351, Sep. 1972.
Bergveld, P., "The Operation of an ISFET as an Electronic Device," Sensors and Actuators, vol. 1, pp. 17-29, Mar. 1981.
Bergveld, P., "Design Considerations for an ISFET Multiplexer and Amplifier," Sensors and Actuators 5 (1984), pp. 13-20.
Blackburn, G. F., Molecular Adsorption Measurement with Chemically Sensitive Field Effect Transistors, Ph.D. Dissertation, University of Utah, Dec. 1983, p. 50.
Blackburn et al., "Field-Effect Transistor Sensitive to Dipolar Molecules," Applied Physics Letters, vol. 43, pp. 700-701, Oct. 1983.
Buck, R. P., "Kinetics and Drift of Gate Voltages for Electrolyte-Bathed Chemically Sensitive Semiconductor Devices," I.E.E.E. Transactions on Electron Devices, vol. ED-29, pp. 108-115, Jan. 1982.
Cheung et al., "Theory, Fabrication, Testing, and Chemical Response of Ion-Sensitive Field-Effect Transistor Devices," in Theory, Design and Bio-Medical Applications of Solid State Chemical Sensors, Cleveland, Ohio: CRC Press, 1978, pp. 92, 103-106, 115.
Compte et al., "A Field Effect Transistor as a Solid-State Reference Electrode," Analytica Chimica Acta, vol. 101, pp. 247-252, Nov. 1978.
Durst, R. A., "Potential Pitfalls in the Use of Ion-Selective Electrode-Reference Electrode Pairs," in Theory, Design and Biomedical Applications of Solid State Chemical Sensors, Cleveland, Ohio: CRC Press, 1978, p. 158.
Esashi et al., "Integrated Micro Multi Ion Sensor Using Field Effect of Semiconductor," I.E.E.E. Transactions on Biomedical Engineering, vol. BME-25, pp. 184-192, Mar. 1978.
Fjeldly et al., "Solid-State Ion-Selective Electrodes with Integrated Electronics," J. Electrochem. Soc: Electrochemical Science and Technology, vol. 126, pp. 793-795, May 1979.
Fjeldly et al., "Fluoride Electrodes with Reversible Solid-State Contacts," J. Electrochem. Soc: Electrochemical Science and Technology (Jun. 1980), pp. 1299-1303.
Frank et al., "Partial Least Squares Solution for Multicomponent Analysis," Analytical Chemistry, vol. 55, pp. 1800-1804, Sep. 1983.
Fricke, G. H., "Ion-Selective Electrodes," Analytical Chemistry, vol. 52, pp. 259R-275R, Apr. 1980.
Gaarenstroom et al., "Computer-Controlled Interference Correction for Ion-Selective Electrode Measurements in a Flowing System," Analytical Chemistry, vol. 50, pp. 811-817, May 1980.
Haemmerli, A. M., Study of Dynamic Characteristics of Ion Selective Field Effect Transistors, Ph.D. Dissertation, University of Utah, Jun. 1982, p. 75.
Haemmerli et al., "Equilibrium Noise in Ion Selective Field Effect Transistors," Journal of the Electrochemical Society, vol. 129, pp. 2306-2312, Oct. 1982.
Haggin, J., "Faster, Smaller Integrated Sensors in Offing for Process Control," C&EN (Jun. 4, 1984), pp. 7-13.
Harame et al., "An Implantable Ion Sensor Transducer," IEEE International Electron Device Meeting Technical Digest, Washington, D.C.: IEEE, 1981, p. 467.
Ho et al., "Encapsulation of Polymeric Membrane-Based Ion-Selective Field Effect Transistors," Sensors and Actuators, vol. 4, pp. 413-421, Nov. 1983.
Huber et al., Solid State Chemical Sensors, New York: Academic Press, 1985, pp. 65-162.
Janata, J., "An Immunoelectrode," Journal of The American Chemical Society, vol. 97, pp. 2914-2916, May 1975.
Janata et al., "Chemically Sensitive Field-Effect Transistor to Detect Organophosphorus Compounds and Pesticides," Aviation, Space, and Environmental Medicine, vo. 52, pp. 666-671, Nov. 1981.
Janata et al., "Chemically Sensitive Field Effect Transistors," in Ion-Selective Electrodes in Analytical Chemistry, vol. 2, H. Freiser, Ed., New York: Plenum Press, 1980, pp. 109, 124, 139, 147, 168-169.
Jochum et al., "Error Propagation and Optimal Performance in Multicomponent Analysis," Analytical Chemistry, vol. 53, pp. 85-92, Jan. 1981.
Janata et al., "Thermodynamics of Chemically Sensitive Field Effect Transistors," in Theory, Design and Biomedical Applications of Solid State Chemical Sensors, Cleveland, Ohio: CRC Press, 1978, pp. 42-46.
Kelly, R. G., "Microelectronic Approaches to Solid State Ion Selective Electrodes," Electrochimica Acta, vol. 22, pp. 1-8, Jan. 1977.
Ko et al., "Multiple ISFET with Integrated Circuits," Sensors and Actuators, vol. 4, pp. 496-500, Jun. 1984.
Kowalski, B. R., "Intelligent Instruments of the Future," in International Union of Food Science and Technology Proceedings from the Food Research and Data Analysis Symposium, Sep. 1982.
Lundstrom et al., "A Hydrogen-Sensitive MOS Field-Effect Transistor," Applied Physics Letters, vol. 26, pp. 55-57, Jan. 1975.
Matsuo et al., "Methods of ISFET Fabrication," Sensors and Actuators, vol. 4, pp. 496-500, Jun. 1984.
McBride et al., "Ion-Selective Field Effect Transistors with Polymeric Membranes," Analytica Chimica Acta, vol. 101, pp. 239-245, Nov. 1978.
McKinley et al., "In Vivo Continuous Monitoring of K.sup.+ in Animals Using ISFETs," Journal of Medical Instrumentation, vol. 24, pp. 93-97, Feb. 1980.
McKinley et al., "In Vivo Continuous Monitoring of Ionized Calcium in Dogs Using Ion Sensitive Field Effect Transistors," Critical Care Medicine, vol. 9, pp. 333-339, Apr. 1981.
Moss et al., "Potassium Ion-Sensitive Field Effect Transistor," Analytical Chemistry, vol. 47, pp. 2238-2243, Nov. 1975.
Moran et al., "Analysis with Ion Selective Electrodes Using the Generalized Standard Addition Method," submitted to Analytical Chemistry, Department of Chemistry, University of Washington.
Oesch et al., "Field Effect Transistors Sensitive to Sodium and Ammonium Ions," Analytical Chemistry, vol. 53, pp. 1983-1986, Nov. 1981.
Poteat et al., "Transition Metal-Gate MOS Gaseous Detectors," I.E.E.E. Transactions on Electron Devices, vol. ED-29, pp. 123-129, Jan. 1982.
Rechnitz, G. A., "Bioselective Membrane Electrode Probes," Science, vol. 214, pp. 287-291, Oct. 1981.
Saxberg et al., "Generalized Standard Addition Method," Analytical Chemistry, vol. 51, pp.

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