Integrated cell culture protein purification system for the auto

Details Integrated cell culture protein purification system for the auto Integrated cell culture protein purification system for the auto

1994-05-06

1996-11-05

Bhat, N.

Chemistry: molecular biology and microbiology

Apparatus

Including condition or time responsive control means

435803, 435813, 435 7021, 4352866, 4352872, 4352971, 4352974, 4352991, 210679, 210194, 210282, C12M 304

Patent

active

055717209

ABSTRACT:
An integrated cell culture-protein purification system has been developed for the continuous, automated production of pure cell culture protein products. The instrument comprises a bioreactor subunit having a hollow fiber bioreactor to culture and maintain cells which secrete the desired product into the cell culture medium. The culture medium is circulated through a purification cartridge which adsorbs the desired product. The system is capable of continuously removing the product from the culture medium by immunoaffinity adsorption and pure product is then recovered. The product can also be recovered automatically in a discontinuous operation from the spent culture medium by either affinity, ion exchange, or hydrophobic purification techniques. The integrated system allows continuous production of high-quality, pure proteins from cell culture.

REFERENCES:
patent: 3328262 (1967-06-01), Lindblom et al.
patent: 3338792 (1967-08-01), Patton et al.
patent: 3767534 (1973-10-01), Miura
patent: 3883393 (1975-05-01), Knazek et al.
patent: 3887432 (1975-06-01), Cawthorne
patent: 3941662 (1976-03-01), Munder et al.
patent: 4033825 (1977-07-01), Haddad et al.
patent: 4206285 (1980-06-01), Poulsen et al.
patent: 4264449 (1981-04-01), Dodd
patent: 4338399 (1982-07-01), Weil et al.
patent: 4425433 (1984-01-01), Neves
patent: 4490290 (1984-12-01), Gani et al.
patent: 4537860 (1985-08-01), Tolbert et al.
patent: 4722902 (1988-02-01), Harm et al.
patent: 4889812 (1989-12-01), Guinn et al.
patent: 4948736 (1990-08-01), Kobayashi et al.
patent: 5026828 (1991-06-01), Yamazaki

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