Integrated active flux microfluidic devices and methods

Details Integrated active flux microfluidic devices and methods Integrated active flux microfluidic devices and methods

2004-03-15

2009-11-24

Warden, Jill (Department: 1797)

Chemical apparatus and process disinfecting, deodorizing, preser

Control element responsive to a sensed operating condition

C422S050000, C422S063000, C422S068100, C422S081000, C422S105000, C422S105000, C422S105000, C436S043000, C436S063000, C436S180000

Reexamination Certificate

active

07622081

ABSTRACT:
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

REFERENCES:
patent: 2656508 (1953-10-01), Coulter
patent: 3560754 (1971-02-01), Kamentsky
patent: 3570515 (1971-03-01), Kinner
patent: 3747628 (1973-07-01), Holster et al.
patent: 4018565 (1977-04-01), Fletcher, III et al.
patent: 4046159 (1977-09-01), Pegourie
patent: 4119368 (1978-10-01), Yamazaki
patent: 4153855 (1979-05-01), Feingold
patent: 4245673 (1981-01-01), Bouteille et al.
patent: 4434704 (1984-03-01), Surjaatmadja
patent: 4581624 (1986-04-01), O'Connor
patent: 4585209 (1986-04-01), Aine et al.
patent: 4675300 (1987-06-01), Zare et al.
patent: 4786165 (1988-11-01), Yamamoto et al.
patent: 4898582 (1990-02-01), Faste
patent: 4908112 (1990-03-01), Pace
patent: 4963498 (1990-10-01), Hillman et al.
patent: 4992312 (1991-02-01), Frisch
patent: 5032381 (1991-07-01), Bronstein et al.
patent: 5085562 (1992-02-01), Van Lintel
patent: 5088515 (1992-02-01), Kamen
patent: 5096388 (1992-03-01), Weinberg
patent: 5126022 (1992-06-01), Soane et al.
patent: 5126115 (1992-06-01), Fujita et al.
patent: 5140161 (1992-08-01), Hillman et al.
patent: 5164558 (1992-11-01), Huff et al.
patent: 5164598 (1992-11-01), Hillman et al.
patent: 5171132 (1992-12-01), Miyazaki
patent: 5224843 (1993-07-01), Van Lintel
patent: 5259737 (1993-11-01), Kamisuki et al.
patent: 5265327 (1993-11-01), Faris et al.
patent: 5271724 (1993-12-01), van Lintel
patent: 5290240 (1994-03-01), Horres, Jr.
patent: 5336062 (1994-08-01), Richter
patent: 5346372 (1994-09-01), Naruse et al.
patent: 5375979 (1994-12-01), Trah
patent: 5376252 (1994-12-01), Ekstrom
patent: 5400741 (1995-03-01), DeTitta et al.
patent: 5417235 (1995-05-01), Wise et al.
patent: 5423287 (1995-06-01), Usami et al.
patent: 5434049 (1995-07-01), Okuno et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5452878 (1995-09-01), Gravesen et al.
patent: 5454472 (1995-10-01), Benecke et al.
patent: 5486335 (1996-01-01), Wilding et al.
patent: 5498392 (1996-03-01), Wilding et al.
patent: 5500071 (1996-03-01), Kaltenbach et al.
patent: 5512131 (1996-04-01), Kumar et al.
patent: 5529465 (1996-06-01), Zengerle et al.
patent: 5558998 (1996-09-01), Hammond et al.
patent: 5580523 (1996-12-01), Bard
patent: 5589136 (1996-12-01), Northrup et al.
patent: 5593130 (1997-01-01), Hansson et al.
patent: 5632876 (1997-05-01), Zanzucchi et al.
patent: 5641400 (1997-06-01), Kaltenbach et al.
patent: 5642015 (1997-06-01), Whitehead et al.
patent: 5659171 (1997-08-01), Young et al.
patent: 5660370 (1997-08-01), Webster
patent: 5661222 (1997-08-01), Hare
patent: 5681024 (1997-10-01), Lisec et al.
patent: 5702618 (1997-12-01), Saaski et al.
patent: 5705018 (1998-01-01), Hartley
patent: 5716852 (1998-02-01), Yager et al.
patent: 5726404 (1998-03-01), Brody
patent: 5726751 (1998-03-01), Altendorf et al.
patent: 5750015 (1998-05-01), Soane et al.
patent: 5757482 (1998-05-01), Fuchs et al.
patent: 5759014 (1998-06-01), Van Lintel
patent: 5775371 (1998-07-01), Pan et al.
patent: 5788468 (1998-08-01), Dewa et al.
patent: 5800690 (1998-09-01), Chow et al.
patent: 5833926 (1998-11-01), Wurzel et al.
patent: 5836750 (1998-11-01), Cabuz
patent: 5837200 (1998-11-01), Diessel et al.
patent: 5837832 (1998-11-01), Chee et al.
patent: 5842787 (1998-12-01), Kopf-Sill et al.
patent: 5852495 (1998-12-01), Parce
patent: 5856174 (1999-01-01), Lipshutz et al.
patent: 5863801 (1999-01-01), Southgate et al.
patent: 5869004 (1999-02-01), Parce et al.
patent: 5875817 (1999-03-01), Carter
patent: 5876187 (1999-03-01), Afromowitz
patent: 5880071 (1999-03-01), Parce et al.
patent: 5904824 (1999-05-01), Oh
patent: 5932799 (1999-08-01), Moles
patent: 5942443 (1999-08-01), Parce et al.
patent: 5948227 (1999-09-01), Dubrow
patent: 5965001 (1999-10-01), Chow et al.
patent: 6007309 (1999-12-01), Hartley
patent: 6007690 (1999-12-01), Nelson et al.
patent: 6015531 (2000-01-01), Colin et al.
patent: 6042709 (2000-03-01), Parce et al.
patent: 6043080 (2000-03-01), Lipshutz et al.
patent: 6103199 (2000-08-01), Bjornson et al.
patent: 6117634 (2000-09-01), Langmore et al.
patent: 6123769 (2000-09-01), Sanjoh
patent: 6155282 (2000-12-01), Zachary et al.
patent: 6174365 (2001-01-01), Sanjoh
patent: 6221654 (2001-04-01), Quake et al.
patent: 6296673 (2001-10-01), Santarsiero et al.
patent: 6318970 (2001-11-01), Backhouse
patent: 6345502 (2002-02-01), Tai et al.
patent: 6409832 (2002-06-01), Weigl et al.
patent: 6540895 (2003-04-01), Quake et al.
patent: 6767706 (2004-07-01), Quake et al.
patent: 6833242 (2004-12-01), Quake et al.
patent: 6960437 (2005-11-01), Enzelberger et al.
patent: 2001/0027745 (2001-10-01), Weigl et al.
patent: 2002/0037499 (2002-03-01), Quake et al.
patent: 2003/0008308 (2003-01-01), Enzelberger et al.
patent: 2004/0115838 (2004-06-01), Quake et al.
patent: 0 592 094 (1994-04-01), None
patent: 0 703 364 (1996-03-01), None
patent: 0 706 004 (1996-04-01), None
patent: 0 745 682 (1996-12-01), None
patent: 0 778 351 (1997-06-01), None
patent: 0 779 436 (1997-06-01), None
patent: 0 829 360 (1998-03-01), None
patent: 0 845 603 (1998-06-01), None
patent: 0 999 055 (2000-05-01), None
patent: 2 155 152 (1985-09-01), None
patent: 2 264 296 (1993-08-01), None
patent: 2 264 496 (1993-09-01), None
patent: 2 308 460 (1997-06-01), None
patent: 09043251 (1997-02-01), None
patent: WO 91/13338 (1991-09-01), None
patent: WO 91/15750 (1991-10-01), None
patent: WO 94/05414 (1994-03-01), None
patent: WO 95/33846 (1995-12-01), None
patent: WO 95/33853 (1995-12-01), None
patent: WO 97/02357 (1997-01-01), None
patent: WO 97/38300 (1997-10-01), None
patent: WO 98/07069 (1998-02-01), None
patent: WO 98/08931 (1998-03-01), None
patent: WO 98/52691 (1998-11-01), None
patent: WO 99/00655 (1999-01-01), None
patent: WO 99/04361 (1999-01-01), None
patent: WO 99/17093 (1999-04-01), None
patent: WO 99/52633 (1999-10-01), None
patent: WO-99/61888 (1999-12-01), None
patent: WO 00/00678 (2000-01-01), None
patent: WO 00/43748 (2000-07-01), None
patent: WO 00/60345 (2000-10-01), None
patent: WO 01/09595 (2001-02-01), None
patent: WO 01/09595 (2001-02-01), None
patent: WO-01/34302 (2001-05-01), None
patent: WO-01/45843 (2001-06-01), None
patent: WO-01/89695 (2001-11-01), None
Angell, et al., “Silicon Micromechanical Devices,” Scientific American, Apr. 1983, 248: pp. 44-55.
Joel S. Bader, et al., “DNA transport by a micromachined Brownian ratchet device,” PNAS, Nov. 9, 1999., vol. 96(23), pp. 13165-13169.
J.P. Brody, et al., “Low Reynolds number micro-fludic devices,” In Proc. of Solid-State Sensor and Actuator Workshop, Jun. 1996, pp. 105-108.
Castro, A., et al., “Fluorescence Detection and Size Measurement of Single DNA Molecules,” Analytical Chemistry, Apr. 1, 1993, vol. 65, pp. 849-852.
N.H. Chiem, et al., “M

Affiliated with

Also associated with

Rating

Integrated active flux microfluidic devices and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Integrated active flux microfluidic devices and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Integrated active flux microfluidic devices and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4088986