Insulinotropic hormone derivatives and uses thereof

Details Insulinotropic hormone derivatives and uses thereof Insulinotropic hormone derivatives and uses thereof

2006-11-21

2006-11-21

Minnifield, Nita (Department: 1645)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Glucagon; related peptides

C530S300000, C530S324000, C530S303000, C514S002600, C514S003100, C514S004300, C514S012200, C514S100000, C514S120000, C514S866000

Reexamination Certificate

active

07138486

ABSTRACT:
Derivatives of glucagon-like peptide I (GLP-1) and especially GLP-1 (7-37) have been found to have insulinotropic activity. The invention pertains to a composition comprising an acid addition salt of GLP-I (7-37) and to a composition comprising a carboxylate salt of GLP-I (7-37). The invention also pertains to method of treating type II diabetes mellitus by providing derivatives of GLP-I (7-37) to the patient.

REFERENCES:
patent: 5118666 (1992-06-01), Habener
patent: 5120712 (1992-06-01), Habener
patent: 5424286 (1995-06-01), Eng
patent: 5512459 (1996-04-01), Wagner et al.
patent: 5545618 (1996-08-01), Buckley et al.
patent: 5574008 (1996-11-01), Johnson et al.
patent: 5614492 (1997-03-01), Habener
patent: 5631224 (1997-05-01), Efendic et al.
patent: 5958909 (1999-09-01), Habener
patent: 5977071 (1999-11-01), Galloway et al.
patent: 6037143 (2000-03-01), Wagner et al.
patent: 6133235 (2000-10-01), Galloway et al.
patent: 6162907 (2000-12-01), Habener
patent: 6191102 (2001-02-01), DiMarchi et al.
patent: RE37302 (2001-07-01), Efendic et al.
patent: 6277819 (2001-08-01), Efendic
patent: 6284725 (2001-09-01), Coolidge et al.
patent: 6284727 (2001-09-01), Kim et al.
patent: 6338053 (2002-01-01), Uehara et al.
patent: 6344180 (2002-02-01), Holst et al.
patent: 6358924 (2002-03-01), Hoffmann
patent: 6380357 (2002-04-01), Hermeling et al.
patent: 6403361 (2002-06-01), Wagner et al.
patent: 6410513 (2002-06-01), Galloway et al.
patent: 6429197 (2002-08-01), Coolidge et al.
patent: 6444788 (2002-09-01), Staby
patent: 6458924 (2002-10-01), Knudsen et al.
patent: 6514500 (2003-02-01), Bridon et al.
patent: 6528846 (2003-03-01), Nowak et al.
patent: 6555521 (2003-04-01), Hermeling et al.
patent: 6849708 (2005-02-01), Habener
patent: 6866843 (2005-03-01), Habener et al.
patent: 6890898 (2005-05-01), Bachovchin et al.
patent: 7056734 (2006-06-01), Egan et al.
patent: 2001/0006943 (2001-07-01), Jensen et al.
patent: 2001/0011071 (2001-08-01), Knudsen et al.
patent: 2001/0014666 (2001-08-01), Hermeling et al.
patent: 2001/0047084 (2001-11-01), Knudsen et al.
patent: 2002/0123466 (2002-09-01), Hoffmann
patent: 2002/0147131 (2002-10-01), Coolidge et al.
patent: 2002/0165342 (2002-11-01), Galloway et al.
patent: 2003/0022823 (2003-01-01), Efendic
patent: 2003/0027996 (2003-02-01), Staby
patent: 2005/0119178 (2005-06-01), Habener
patent: 2006/0094652 (2006-05-01), Levy et al.
patent: 19530865 (1997-02-01), None
patent: 0 044 168 (1982-01-01), None
patent: 0 082 731 (1983-06-01), None
patent: 0 305 387 (1989-03-01), None
patent: 587255 (1994-03-01), None
patent: 0 619 322 (1994-10-01), None
patent: 0 658 568 (1995-06-01), None
patent: 0 733 644 (1996-09-01), None
patent: 1498425 (2005-01-01), None
patent: 2 732 894 (1996-10-01), None
patent: 1-502746 (1989-09-01), None
patent: 2583257 (1989-09-01), None
patent: 2001151798 (2001-06-01), None
patent: 2003192698 (2003-07-01), None
patent: 2004196825 (2004-07-01), None
patent: 2005132848 (2005-05-01), None
patent: WO 87/06941 (1987-11-01), None
patent: WO 90/11296 (1990-10-01), None
patent: WO 91/11457 (1991-08-01), None
patent: WO 93/18786 (1993-09-01), None
patent: WO 93/19175 (1993-09-01), None
patent: WO 93/25579 (1993-12-01), None
patent: WO 95/03405 (1995-02-01), None
patent: WO 95/05848 (1995-03-01), None
patent: WO 95/07098 (1995-03-01), None
patent: WO 95/17510 (1995-06-01), None
patent: WO 95/31214 (1995-11-01), None
patent: WO 96/20005 (1996-07-01), None
patent: WO 98/19698 (1998-05-01), None
Albano, J.D.M., et al., “A Sensitive, Precise Radioimmunoassay of Serum Insulin Relying on Charcoal Separation of Bound and Free Hormone Moieties,”Acta Endocrinologica(Copenh.) 70:487-509, Munksgaard (1972).
Andersen, D.K., et al., “The Insulinotropic Effect of GIP: A Dose Response Comparison and Comparison to Glucagon-Like Peptide-1(7-37) amide (GLP),”Diabetes 39: 142A, American Diabetes Association, Abstract No. 567 (May 1990).
Andrews, P.C., and Ronner, P., “Isolation and Structures of Glucagon and Glucagon-like Peptide from Catfish Pancreas,”J. Biol. Chem. 260:3910-3914, The American Society for Biochemistry and Molecular Biology, Inc. (Apr. 1985).
Bell, G.I., et. al., “Hamster preproglucagon contains the sequence of glucagon and two related peptides,”Nature 302:716-718, Macmillan Publishers Ltd. (1983).
Blackmore, P.F., et. al., “Absence of insulinotropic glucagon-like peptide-I (7-37) receptors on isolated rat liver hepatocytes,”FEBS Lett. 283:7-10, Elsevier Science Publishers B.V. (May 1991).
Bromer, W.W., et. al., “Amino Acid Sequence of Bovine Glucagon,”J. Biol. Chem. 246:2822-2827, American Society of Biological Chemists, Inc. (1971).
Buhl, T., et. al., “Naturally Occurring Products of Proglucagon 111-160 in the Porcine and Human Small Intestine,”J. Biol. Chem. 263:8621-8624, The American Society for Biochemistry and Molecular Biology, Inc. (Jun. 1988).
Creutzfeldt, W., et. al., “Entero-Insular Axis 1988,” inDiabetes 1988, Larkins, R., et. al., eds., Elsevier Science Publishers B.V. (Biomedical Division), Amsterdam, The Netherlands, pp. 193-203 (May 1989).
Dobbs, R., et. al., “Glucagon: Role in the Hyperglycemia of Diabetes Mellitus,”Science 187:544-547, American Association for the Advancement of Science (1975).
Dobs, A.S., et. al., “Regulation of Insulin Synthesis in an Insulin-Producing Cell Line (RlNm5F): Long-Term Experiments,”In Vitro Cell. Dev. Biol. 25:112-114, Society for In Vitro Biology (Feb. 1989).
Drucker, D.J., et. al., “Cell-specific Post-translational Processing of Preproglucagon Expressed from a Metallothionein-glucagon Fusion Gene,”J. Biol. Chem. 261:9637-9643, The American Society of Biological Chemists, Inc. (Jul. 1986).
Drucker, D.J., et. al., “Glucagon-like Peptide I Increases Insulin mRNA Levels and Insulin Release in Rat Insulinoma Cells,”Programs and Abstracts book, 68thAnnual Meeting of The Endocrine Society, Jun. 25-27, 1986, Anaheim, CA, Abstract No. 602 (Jun. 1986).
Drucker, D.J., et. al., “Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line,”Proc. Natl. Acad. Sci. USA 84:3434-3438, The National Academy of Sciences (May 1987).
Fehmann, H.C., et. al., “Functional receptors for the insulinotropic hormone glucagon-like peptide-I (7-37) on a somatostatin secreting cell line,”FEBS Lett. 279:335-340, Elsevier Science Publishers B.V. (Feb. 1991).
Fehmann, H.C., et al., “Insulinotropic Hormone Glucagon-like Peptide-I (7-37) Stimulation of Proinsulin Gene Expression and Proinsulin Biosynthesis in Insulinoma βTC-1 Cells,”Endocrinology 130:159-166, The Endocrine Society (Jan. 1992).
Fehmann, H.-C., and Habener, J.F., “Galanin Inhibits Proinsulin Gene Expression Stimulated by the Insulinotropic Hormone Glucagon-Like Peptide-I (7-37) in Mouse Insulinoma βTC-1 Cells,”Endrocrinology 130:2890-2896, The Endocrine Society (May 1992).
Fehmann, H.-C., and Habener, J.F., “Insulinotropic Glucagonlike Peptide-I (7-37)/(7-36) Amide: A New Incretin Hormone,”Trends in Endocrinology and Metabolism 3:158-163, Elsevier Science Publishing Co. (Jul. 1992).
Ganong, W.F., “Endocrine Functions of the Pancreas & the Regulation of Carbohydrate Metabolism,” inReview of Medical Physiology, Foltin, J., et. al., eds., LANGE Medical Publications, Los Altos, CA, pp. 257-276 (1979).
Garcia, S.D., et. al., “Biosynthesis of Proinsulin and Insulin in Newborn Rat Pancreas,”J. Clin. Invest. 57:230-243, The American Society for Clinical Investigation (1976).
Gefel, D., et. al., “Glucagon-Like Peptide-I Analogs: Effects on Insulin Secretion and Adenosine 3′, 5′-Monophosphate Formation,”Endocrinology 126:2164-2168, The Endocrine Society (Apr. 1990).
George, S.K., et. al., “Molecular forms of glucagon-like peptides in man,”FEBS Lett. 192:275-278, Elsevier Science Publishers B.V. (No

Affiliated with

Also associated with

Rating

Insulinotropic hormone derivatives and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Insulinotropic hormone derivatives and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Insulinotropic hormone derivatives and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3633665