Insulin receptor tyrosine kinase substrate

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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536 235, 536 231, 530350, 4353201, 435325, 4352523, C12N 1500

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active

058916741

ABSTRACT:
The invention provides a human insulin receptor tyrosine kinase substrate (IRS-p53h) and polynucleotides which identify and encode IRS-p53h. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of IRS-p53h.

REFERENCES:
White, M.F. et al., "The Insulin Signaling System", J. Biol. Chem., 269: 1-4 (1994).
Almind, K. et al., "A Common Amino Acid Polymorphism in Insulin Receptor Substrate-1 Causes Impaired Insulin Signaling", J. Clin. Invest., 97: 2569-2575 (1996).
Yeh, T. et al., "Characterization and Cloning of a 58/53-kDa Substrate of the Insulin Receptor Tyrosine Kinase", J. Biol. Chem., 271: 2921-2928 (1996).
Stoffel, M. et al., "Human insulin receptor substrate-1 gene (IRS1) : chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism", Diabetologia, 36: 335-337 (1993).
Yeh, T.C. et al., (Direct Submission), GenBank Sequence Database (Accession 1203820), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1203820).
Yeh, T.C. et al., (Direct Submission), GenBank Sequence Database (Accession U41899), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1203819; GI 1203820).
Hillier et al., Accession No. R55195, The WashU-Merck EST project, May 22, 1995.
Marra et al., Accession No. AA061801 (The Marra M/Mouse EST Project), Sep. 23, 1996.
Hillier et al., Accession No. AA235829, The WashU-Merck EST project, Mar. 6, 1997.

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