Insulin receptor-related receptor binding protein

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S002600, C514S008100, C530S350000

Reexamination Certificate

active

06872703

ABSTRACT:
A protein or a variant thereof, which has a binding activity to IRR and the following characteristics and an insulin receptor-related receptor are allowed to bind in the presence of a test substance, and inhibition of the binding is measured to search for an agonist or antagonist of IRR ligand.(a) it has the amino acid sequence of SEQ ID NO: 1;(b) it has a molecular weight measured by mass spectrometry using the Fourier transformation ion cyclotron method of about 6135, 6206, 6250 or 6321.

REFERENCES:
patent: WO 9115510 (1991-10-01), None
patent: WO 9315195 (1993-08-01), None
patent: WO 9852607 (1998-11-01), None
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V. Bhandari, et al., Proc. Natl. Acad. Sci., vol. 89, pps. 1715-1719, “Isolation and Sequence of the Granulin Precursor cDNA from Human Bone Marrow Reveals Tandem Cysteine-Rich Granulin Domains,” Mar. 1992.
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