Insulin receptor

Details Insulin receptor Insulin receptor

1985-02-12

1988-08-02

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 70, 435 91, 4351723, 435320, 536 27, 935 29, 935 32, 935 56, C12P 2100, C12P 1934, C12N 1500, C07H 1512

Patent

active

047613718

ABSTRACT:
Insulin receptor is purified in accordance with this invention to a level sufficient to enable amino acid sequencing thereof. DNA encoding insulin receptor is provided, as well as methods for synthesizing insulin receptor or its mutant in heterologous host cells transformed with vectors containing such DNA. Knowledge of the amino acid sequence for insulin receptor enables the preparation of novel immunogenic conjugates and antibodies raised against such conjugates. Novel therapeutically useful forms of the insulin receptor and anti-receptor antibodies are described.

REFERENCES:
Petruzzelli, L., et al., "Proc. Natl. Acad. Sci. USA" 81: 3327-3331 (Jun. 1984).
Cobb, M. H. et al. "Biochim. et Biophys. Acta" 738: 1-8 (1984).
Ullrich et al., (1984) Nature, vol. 309, pp. 418-425.
Downward et al. (1984) Nature, vol. 307, pp. 521-527.
Siegel et al. (1981) J. Biol. Chem., vol. 256, pp. 9266-9273.
King et al. (1982) J. Biol. Chem., vol. 2257, pp. 10869-10873.

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