Insulin prodrugs hydrolyzable in vivo to yield peglylated...

Details Insulin prodrugs hydrolyzable in vivo to yield peglylated... Insulin prodrugs hydrolyzable in vivo to yield peglylated...

2007-01-30

2007-01-30

Russel, Jeffrey E. (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

C514S003100

Reexamination Certificate

active

10018879

ABSTRACT:
The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, and oleic acid can be orally administered.

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