Insulin-potentiating peptides

Details Insulin-potentiating peptides Insulin-potentiating peptides

1983-07-15

1985-01-29

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601125R, A61K 3700, C07C10352

Patent

active

044965214

ABSTRACT:
hGH(1-43) having the formula: H--Phe--Pro--Thr--Ile--Pro--Leu--Ser--Arg--Leu--Phe--Asp--Asn--Ala--Met--L eu--Arg--Ala--His--Arg--Leu--His--Gln--Leu--Ala--Phe--Asp--Thr--Try--Gln--G lu--Phe--Glu--Glu--Ala--Try--Ile--Pro--Lys--Glu--Gln--Lys--Tyr--Ser--OH has been found to have remarkable insulin-potentiating action, as has the fragment hGH (17-43). Pharmaceutical compositions in accordance with the invention include hGH(1-43), hGH(17-43) or a biologically active intermediate fragment, or a nontoxic salt thereof, dispersed in a pharmaceutically acceptable carrier. Such peptides or pharmaceutically acceptable salts thereof may be administered to mammals to promote the action of insulin.
Such a peptide can be synthesized by exclusively solid-phase techniques, by partial solid-phase techniques, by fragment condensation, by classical solution addition or by recently developed recombinant DNA techniques.

REFERENCES:
Biol. Abstr. vol. 71, (1981) 73108.
Biol. Abstr. vol. 66, (1978) 51517.
Biol. Abstr. vol. 67, (1979) 45020.
Biol. Abstr. vol. 68, (1979) 47102.
Biol. Abstr. vol. 66, (1978) 70048.
Biol. Abstr. vol. 70, (1980) 77740.
Biol. Abstr. vol. 70, (1980) 4531.

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