Insulin mediator substance

Details Insulin mediator substance Insulin mediator substance

1980-12-19

1984-05-01

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 424 95, C07G 700

Patent

active

044460643

ABSTRACT:
An insulin mediator substance produced by the process comprising: contacting muscle tissue with insulin; deproteinizing the muscle tissue; removing the major nucleotides from the deproteinized muscle tissue; chromatographing the so-treated product on a Sephadex G-25 column using 0.05 N formic acid; and recovering the fraction wherein the major 230-nm absorbance peak corresponds with the ninhydrin-positive peak.

REFERENCES:
patent: 1626044 (1927-04-01), Macy
patent: 3326763 (1967-06-01), Antoniades
Fed. Proc. Fed. AM Soc. Exp. Biol. 33, 261 (1974), Larner et al.
Science, vol. 206, Dec. 21, 1977, pp. 1407-1408, Jarett et al.
Science, vol. 206, Dec. 21, 1979, Larner et al.

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