Insulin-like growth factor I (IGF-1) induced improvement of depr

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4241851, 514 2, 514 12, 514 21, 530300, 530350, 530399, 530868, A61K 3830, A61K 4505

Patent

active

057441391

ABSTRACT:
A method for increasing the T4/T8 ratio in a human with a depressed T4/T8 ratio comprising administering insulin-like growth factor I (IGF-1) is disclosed.

REFERENCES:
patent: 4189426 (1980-02-01), Li
patent: 4342832 (1982-08-01), Goeddel et al.
patent: 4446235 (1984-05-01), Seeburg
patent: 4621053 (1986-11-01), Sugimoto
patent: 4755465 (1988-07-01), Gray et al.
patent: 4769361 (1988-09-01), Burleigh et al.
patent: 4791099 (1988-12-01), Aroonsakul
patent: 4816439 (1989-03-01), Jorgensen
patent: 4833166 (1989-05-01), Grosvenor et al.
patent: 4837202 (1989-06-01), Edwards, III et al.
patent: 4859600 (1989-08-01), Gray et al.
patent: 4863901 (1989-09-01), Wilmore
patent: 4898830 (1990-02-01), Goeddel et al.
patent: 4939124 (1990-07-01), Cacabelos
patent: 5028591 (1991-07-01), Edwards, III et al.
patent: 5077276 (1991-12-01), Ballard et al.
patent: 5202119 (1993-04-01), Clark et al.
patent: 5317012 (1994-05-01), Kudsk
Johnson, E.W. & Kozak, R.W., "Expression and Function of Insulin-like Growth Factor Receptors on Activated T Lymphocytes," Endocrine Society 73rd Annual Meeting, Abstract. #1073, p. 299, Jun. 19-22, 1991.
Timsit, J. et al., "Effects of Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1) on Thymic Hormonal Function in Man," Endocrine Society 73rd Annual Meeting, Abstract. #1296, p. 354, Jun. 19-22, 1991.
Baroni, C., "Thymus, Peripheral Lymphoid Tissues and Immunological Responsiveness of the Pituitary Drawf Mouse," Experientia 23(4):282-283 (1967).
Roth, J.A. et al., "Improvement in Clinical Condition and Thymus Morphologic Features Associated With Growth Hormone Treatment of Immunodeficient Dwarf Dogs," Am. J. Vet. Res. 45(6):1151-1155 (1984).
Schimpff, R.-M. et al., "Effect of Purified Somatomedins on Thymidine Incorporation into Lectin-Activated Human Lymphocytes," Acta Endocr. 102:21-26 (1983).
Fabris, N. et al., "Hormones and the Immunological Capacity, III. The Immunodeficiency Disease of the Hypopituitary Snell-Bagg Dwarf Mouse" Clin Exp. Immunol. 9:209-225 (1971).
Baroni, C.D. et al., "Effects of Hormones on Development and Function of Lymphoid Tissues. Synergistic Action of Thyroxin and Somatotropic Hormone in Pituitary Dwarf Mice," Immunology 17:303-314 (1969).
Rom, W.N. et al., "Alveolar Macrophages Release an Insulin-Like Growth Factor I-Type Molecule," J. Clin. Invest. 82:1685-1693 (1988).
Murphy, L.J., et al., "Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat," Endocrinology 120(4):1279-1282 (1987).
Merimee, T.J. et al., "Insulin-Like Growth Factor Secretion by Human B-Lymphocytes: A Comparison of Cells from Normal and Pygmy Subjects," J. Clin. Endocr. & Metab. 69(5):978-984 (1989).
Merchav, S. et al., "Enhancement of Human Granulopoiesis In Vitro by Biosynthetic Insulin-Like Growth Factor I/Somatomedin C and Human Growth Hormone," J. Clin. Invest. 81:791-797 (1988).
Kozak, R.W., et al., "Type I and II Insulin-Like Growth Factor Receptors on Human Phytohemagglutinin-Activated T Lymphocytes," Cellular Immunol. 109:318-331 (1987).
Kelley, K.W., "Growth Hormone, Lymphocytes and Macrophages," Biochem. Pharmacol. 38(5):705-713 (1989).
Fu, Y.-K. et al., "A Novel Role of Growth Hormone and Insulin-Like Growth Factor-I," J. Immunol. 146(5):1602-1608 (1991).
Marsh, J.A. et al., "Enhanced Growth and Immune Development in Dwarf Chickens Treated with Mammalian Growth Hormone and Thyroxine," Proc. Soc. Exp. Biol. & Med. 175:351-360 (1984).
Pierpaoli, W. and Sorkin, E., "Relationship Between Thymus and Hypophysis," Nature 215:834-837 (1967).
Murphy, W.J. et al., "Growth Hormone Accelerates Peripheral T Cell Reconstitution in Mice with Severe Combined Immune Deficiency," The FASAB Journal 75th Annual Meeting, Abstracts -Part III, Atlanta, Georgia, vol. 5, No. 6, Apr. 21-25, 1991, Abstract No. 7538, p. A1669.
Durum, S.K. et al., "CD4/CD8 Differentiation of T Cells in Mice with Severe Combined Immunodeficiency (SCID) Without Receptor Rearrangement," The FASAB Journal 75th Annual Meeting, Abstracts, Part III, Atlanta, Georgia, vol. 5, No. 6, Apr. 21-25, 1991, Abstract No. 7567, p. A1674.
Stuart, C.A., et al., "Insulin-Like Growth Factor-I Binds Selectively to Human Peripheral Blood Monocytes and B-Lymphocytes," J. Clin. Endocr. & Metab. 72(5):1117-1122 (1991).
Guler, H.-P. et al., "Recombinant Human Insulin-Like Growth Factor I Stimulates Growth and has Distinct Effects on Organ Size in Hypophysectomized Rats," Proc. Natl. Acad. Sci. USA 85:4889-4893 (1988).
Ammann, A.J., "Growth Hormone and Immunity," Human Growth Hormone, Progress and Challenges, L.E. Underwood, Ed., Marcel Dekker, Inc., NY, pp. 243-253 (1987).
DePasquale-Jardieu, P. & Fraker, P.J., "Further-Characterization of the Role of Corticosterone in the Loss of Humoral Immunity in Zinc-Deficient A/J Mice as Determined by Adrenalectomy," J. Immunol. 124(6):2650-2655 (1980).
Goff, B.L. et al., "Growth Hormone Treatment Stimulates Thymulin Production in Aged Dogs," Clin. Exp. Immunol. 68:580-587 (1987).
Geffner, M.E. et al., "Growth Hormone Mediates the Growth of T-Lymphoblast Cell Lines via Locally Generated Insulin-Like Growth Factor-I," J. Clin. Endocr. Metab. 71(2):464-469 (1990).
Tapson, V.F. et al., "Structural and Functional Characterization of the Human T Lymphocyte Receptor for Insulin-Like Growth Factor I In Vitro," J. Clin. Invest. 82:950-957 (1988).
Franco, P. et al., "Influence of Growth Hormone on the Immunosuppressive Effect of Prednisolone in Mice," Acta Endocrin. (Copenh) 123:339-344 (1990).
Hunt P. and Eardley, D.D., "Suppressive Effects of Insulin and Insulin-Like Growth Factor-1 (IGF1) on Immune Responses," J. Immunol. 136(11):3994-3999 (1986).
Weigent, D.A. et al., "Growth Hormone and the Immune System," Progress in NeuroEndocrinImmunology 3(4):231-241 (1990).
Froesch, E.R. et al., "Growth Hormone--Basic and Clinical Aspects. Growth-Promoting and Hypoglycemic Effects of Human Recombinant IGF I In Vivo in the Context of In Vitro Actions of IGF I," O. Isaksson, et al., Eds., Proceedings of the 1st Nordisk Insulin Symposium, Stockholm, Sweden, Jun. 29-Jul. 1, 1987, Excerpta Medica, Amsterdam, pp. 321-336 (1987).
Binz, K. et al., "Repopulation of the Atrophied Thymus in Diabetic Rats by Insulin-Like Growth Factor I," Proc. Natl. Acad. Sci. USA 87:3690-3694 (1990).
Kurtz, A. et al., "Insulin-Like Growth Factor I Stimulates Erythropoiesis in Hypophysectomized Rats," Proc. Natl. Acad. Sci. USA 85:7825-7829 (1988).
Kelley, K.W., "Growth Hormone in Immunobiology," Psychoneuroimmunology, 2nd
Kiess, W. et al., "Lymphocyte Subset Distribution and Natural Killer Activity in Growth Hormone Deficiency Before and During Short-Term Treatment with Growth Hormone Releasing Hormone," Clin. Immunol. & Immunopath. 48:85-94 (1988).
Pandian, M.R. et al., "Effect of Growth Hormone on the Metabolism of Thymus and on the Immune Response Against Sheep Erythrocytes," J. Exp. Med. 134:1095-1113 (1971).
Gupta, S.M. et al., "Immunological Studies in Patients with Isolated Growth Hormone Deficiency," Clin. Exp. Immunol. 54:87-90 (1983).
Savino, W. et al., "Thymic Hormone Containing Cells. II. Evolution of Cells Containing the Serum Thymic Factor (FTS or Thymulin) in Normal and Autoimmune Mice, as Revealed by Anti-FTS Monoclonal Antibodies. Relationship With Ia Bearing Cells," Clin. Exp. Immunol. 52:1-6 (1983).
Rapaport, R.R. et al., "Suppression of Immune Function in Growth Hormone-Deficient Children During Treatment with Human Growth Hormone," J. Pediatr. 109(3):434-439 (1986).
Bozzola, M. et al., "Immunological and Endocrinological Response to Growth Hormone Therapy in Short Children," Acta Paediatr. Scand. 77:675-680 (1988).
Rapaport, R. et al., "Effects of Human Growth Hormone on Immune Functions: In Vitro Studies on Cells of Normal and Growth Hormone Deficient Children," Life Sciences 41(20):2319-2324 (1987).
Verland, S. et al., "Functional Receptors for Insulin-Like Growth Factors I and II in Rat Thymocytes and Mouse Thymoma Cells," Mol. & Cell. Endocr. 67:207-216 (1989).
Timsit, J. et al., "Augmentation Des Taux Circulants de Thymuline au Cours de L'Hyperpr

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Insulin-like growth factor I (IGF-1) induced improvement of depr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Insulin-like growth factor I (IGF-1) induced improvement of depr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Insulin-like growth factor I (IGF-1) induced improvement of depr will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1529872

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.