Insulin-like growth factor binding protein (IGFBP-6)

Details Insulin-like growth factor binding protein (IGFBP-6) Insulin-like growth factor binding protein (IGFBP-6)

1997-08-25

2000-02-15

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530399, 514 3, 514 12, 435 694, A61K 3726, A61K 3736, C07K 1300, C12P 2102

Patent

active

060254653

ABSTRACT:
A purified binding protein selected from the group consisting of insulin-like growth factor binding protein having an amino acid sequence which is at least 85% homologous to the amino acid sequence of FIG. 1 and fragments thereof comprising at least 10 consecutive amino acids of the sequence that are capable of binding to an antibody specific for the protein or to an insulin-like growth factor is described. Recombinant DNA molecules encoding the binding proteins and subsequences thereof are also described along with recombinant microorganisms and cell lines containing the DNA molecules and methods for preparing the binding proteins by growing the recombinant hosts containing the relevant DNA molecules. Antibodies to the protein, identified as IGFBP-6, which are useful in various diagnostic applications, are also described.

REFERENCES:
patent: 4888414 (1989-12-01), Knutson
Cubbage et al., "Insulin-Like Growth Factor Binding Protein-3," J. of Biological Chemistry 265(21):12642-12649.
Roghani et al., "Isolation From Human Cerebrospinal Fluid of a New Insulin-Like Growth Factor-Binding Protein with a Selective Affinity for IGF-II," FEBS Letters 255(2):253-258 (1989).
Povoa, et al., Isolation and Characterization of a Somatomedin-Binding Protein from Mid-term Human Amniotic Fluid, Eur. J. Biochem, Jul. 1984, 144:199-204.
Koistinen, et al., Placental Protein 12 is a Decidual Protein that Binds Somatomedin and has an Identical N-Terminal Amino Acid Sequence . . . , Endocrinology, 1986, 118:1375-1378.
Powell, et al., Method for Purification of an Insulin-Like Growth Factor-Binding Protein Produced by Human HEP G2 Hepatoma Cells, Journal of Chromatography, 420, 1987, 420:163.
Lee, et al., Insulin-Like Growth Factor (IGF) Binding Protein Complementary Deoxyribo-Nucleic Acid from Human HEP G2 Hepatoma Cells . . . , Mol. Endocrinology, 1988, 2:404-411.
Brinkman, et al., Isolation and Characterization of cDNA Encoding the Low Molecular Weight Insulin-Like Growth Factor Binding Protein (IBP-1), EMBO Journ., 1988, 7:2417-2423.
Brewer, et al., Cloning, Characterization, and Expression of a Human Insulin-Like Growth Factor Binding Protein, Biochemical and Biophysical Research Com., 1986, 152:1289-1297.
Binkert, et al., Cloning, Sequence Analysis and Expression of a cDNA Encoding a Novel Insulin-Like Growth Factor . . . , EMBO Journ., 1989, 8:2497-2502.
Baxter, et al., Growth Hormone-Dependent Insulin-Like Growth Factor (IGF) Binding Protein From Human Plasma . . . , Biochemical and Biophysical Research Com. 1986, 139:1256-1261.
Wood, et al., Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein, Molecular Endocrinology, 1988, 2:1176-1185.
Mottola, et al., Purification and Amino-Terminal Sequence of an Insulin-Like Growth Factor Binding Protein Secreted by Rat Liver . . . , Journ. of Biol. Chem., 261:11180-11188.
Lyons, et al., Characterization of Multiplication-Stimulating Activity (MSA) Carrier Protein, Mol. Cell. Endocrinol., 1986, 45:263-270.
Mohan, et al., Isolation of an Inhibitory Insulin-Like Growth Factor (IGF) Binding Binding Protein From Bone . . . , Proc. Natl. Acad. Sci., 1989, 86:8338-8342.
Zapf, et al., Isolation from Adult Human Serum of Four Insulin-Like Growth Factor . . . , Journal of Biological Chemistry, 1990, 265:14892-14898.
Shimasaki, et al., Molecular Cloning of the cDNAs Encoding a Novel Insulin-Like Growth Factor-Binding Protein From Rat and Human, Mol. Endocrinology, 1990, 4:1451-1458.
U.S. Serial No. 07/574,613 Aug. 28,1990 Kiefer, et al.
U.S. Serial No. 07/577,391 Aug. 31,1990 Kiefer, et al.
U.S. Serial No. 07/576,629 Aug. 31,1990 Kiefer, et al.
U.S. Serial No. 07/577,392 Aug. 31,1990 Kiefer, et al.
Marino 1990 in Recombinent DNA Technologies and Application Eds Prolop, Bajpai, & Ho. McGraw-Hill, NY 29-65.
Baxter & Martin 1987 Binding Prot. for JLG7 in adult rat serum. Comp. with human & rat BP. Biochem Biophys. Res. Commun. 147:408.

Affiliated with

Also associated with

Rating

Insulin-like growth factor binding protein (IGFBP-6) does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Insulin-like growth factor binding protein (IGFBP-6), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Insulin-like growth factor binding protein (IGFBP-6) will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1906924