Insulin/IGF/relaxin family polypeptides and DNAS thereof

Details Insulin/IGF/relaxin family polypeptides and DNAS thereof Insulin/IGF/relaxin family polypeptides and DNAS thereof

2006-05-23

2006-05-23

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C530S399000, C514S002600, C514S012200, C424S198100

Reexamination Certificate

active

07049403

ABSTRACT:
The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt, (4) DNAs encoding the same, etc.These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.

REFERENCES:
patent: WO 99/15664 (1999-04-01), None
patent: WO 00/21996 (2000-04-01), None
patent: WO 00/32221 (2000-06-01), None
patent: WO 00/47776 (2000-08-01), None
patent: WO 01/68862 (2001-09-01), None
patent: WO 02/22802 (2002-03-01), None
Bullesbach et al., SEQ ID No: 7 sequence alignment result.
Bullesbach et al., SEQ ID No: 8 sequence alignment result.
Bullesbach, et al. “Isolation, purification, and the sequence of relaxin from spiny dogfish (Squalus acanthias)” Eur. J. Biochem. 161: 335-341 (1986).
Gowan, et al., On the Primary and Tertiary Structure of Relaxin from The Sand Tiger Shark (Odontaspis taurus) Febs Letters 129(1): 80-82(Jun. 1981).
Haley, et al., “Porcine Relaxin—Gene Structure and Expression” The Journal of Biological Chemistry 262(25):11940-11946 (1987).
James, et al., “Primary structure of porcine relaxin: homology with insulin and related growth factors” NATURE 267:544-546 (Jun. 9, 1977).
Berger, et al. “Stastical Approach for Evolutionary Relationship of α-Conotoxins and Members of Insulin-Superfamily” Horm. Metab. Res. 28:535-540(1996).
Daniele Bani “Relaxin: A Pleiotropic Hormone” Gen. Pharmac. 28(1): 13-22 (1997).
Büllesbach, et al. “The Relaxin-Like Factor Is a Hormone” ENDOCRINE 10(2): 167-169 (Apr. 1999).
XP-002282992, Jan. 27, 2000, EMBL:AC022098.

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