Insulin dispenser for peritoneal cavity

Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...

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604244, A61F 100

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047816937

ABSTRACT:
An implant device for introduction of insulin into the peritoneal cavity which permits a flexible catheter to be removed and replaced without invasive surgery. The catheter is passed through a substantially rigid percutaneous body and a distally extending catheter conduit which together form a continuous conduit from the body exterior through the peritoneal wall. A polytetrafluoroethylene polymer sleeve allows tissue ingrowth to secure the body to the epidermis. A polyethylene terephthalate portion of the sleeve provides tissue ingrowth to stabilize the implant and prevent extrusion from the dermis. The catheter is associated with the percutaneous tubular body so as to be removable and replaceable through the conduit thereformed after implantation. The catheter preferably terminates within the interior cavity of the percutaneous body and is sealed from the environment by means of a septum closure within the device cavity. A sponge saturated with antiseptic is fitted in the body recess above the septum and is closed off from the environment by a penetrable cap member. The saturated sponge prevents the introduction of bacteria into the peritoneum.

REFERENCES:
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patent: 4306976 (1981-12-01), Bazzato
patent: 4405320 (1983-09-01), Cracauer et al.
patent: 4488877 (1984-12-01), Klein et al.
patent: 4512761 (1985-04-01), Raible
"The Peritoneum-A Potential Insuline Delivery Route for a Mechanical Pancreas", by David S. Schade and Philip Eaton, reprinted from Diabetes Care, vol. 3, No. 2, Mar.-Apr., 1980.
"Stabilization and Improvement of Renal Function in Diabetic Nephrophathy", by Robert L. Stephen et al, published in Diabetic Nephropathy, vol. 1, No. 1, 11/82.
"Multiple Daily Insulin Injections Through Subcutaneously Implanted Needle, by G. Slama et al, printed in Letters to the Editor in The Lancet, 5/1980, p. 1780.
"The Role of Biomaterials in Insulin Delivery Systems", by S. D. Brucke, The international Journal of Artificial Organs, vol. 3, No. 5, 1980, pp. 299-304.
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"Multiple Use of Disposable Insulin Syringe-Needle Units", by Robert Hodge, Jr. et al, JAMA, 7/18/80, vol. 244, No. 3.
"Outpatient Treatment of Juvenile-Onset Diabetes with a Preprogrammed Portable Subcutaneous Insulin Infusion System", by W. V. Tamborlane, et al, The American Journal of Medicine, vol. 68, 2/1980.
"Intraperitoneal Administration of Insulin During Peritoneal Dialysis of Diabetics with Terminal Renal Failure", by K. E. Hemmeloff Andersen et al, The International Journal of Artificial Organs, vol. 4, No. 4, 1981, pp. 162-167.
"Continuous Ambulatory Peritoneal Dialysis in Diabetic Patients", by C. T. Flynn Capd in Diabetes, pp. 187-193.
"The Peritoneal Absorption of Insulin in Diabetic Man: A Potential Site for a Mechanical Insuline Delivery System", by D. S. Schade, et al, Metaorganism, vol. 28, No. 3, Mar. 1979.
"Investigations of Risks and Hazards with Devices Associated with Peritoneal Dialysis (Including Intermittent Peritoneal Dialysis and Continuous Ambulatory Peritoneal Dialysis) and Sorbent Regenerated Dialysate Delivery Systems, revised Draft Report for FDA Contract No. 223-81-5001 (6/82).

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